2 citations
,
February 2023 in “BMC women's health” In this study, oral contraceptive use in women with PCOS increased the expression of certain inflammatory gene markers, which were positively associated with metabolic abnormalities.
169 citations
,
August 2004 in “Baillière's best practice & research. Clinical obstetrics & gynaecology/Baillière's best practice and research in clinical obstetrics and gynaecology” This article discusses treatments for hirsutism and acne in women with polycystic ovary syndrome, suggesting that lower doses of current medications maintain efficacy while reducing cost and side effects, but reports no new clinical results.
75 citations
,
November 2007 in “Clinical endocrinology” This study found that several drugs, including flutamide and spironolactone, significantly reduced hirsutism in women, with reduced effectiveness in those with higher BMI.
74 citations
,
December 1995 in “The Journal of Clinical Endocrinology & Metabolism” This study found that treatment with leuprolide plus cyclic estrogen/progestin may lead to a faster and greater improvement in hirsutism compared to a standard oral contraceptive regimen.
67 citations
,
March 2018 in “The Journal of Clinical Endocrinology & Metabolism” This study reported that estrogen-progestin oral contraceptives, antiandrogens, and insulin sensitizers are more effective than placebo in treating hirsutism in women, with combination therapies generally proving superior to monotherapy.
53 citations
,
April 2016 in “PubMed” This review discusses the relationship between PCOS and hirsutism, exploring inflammatory markers and treatment options, and concludes that combining metformin with OCP may benefit both normal weight and obese PCOS patients.
47 citations
,
July 2016 in “Current pharmaceutical design” This review summarizes hair growth aspects, treatment options, and management strategies for hirsutism in women with polycystic ovary syndrome, without presenting new clinical findings.
43 citations
,
September 2012 in “International Journal of Dermatology” This review describes a practical approach for dermatologists to manage adult female acne using hormonal therapies and highlights the importance of identifying possible underlying endocrine disorders like PCOS, but it does not report new findings.
42 citations
,
July 2015 in “Journal of The American Academy of Dermatology” This review discusses diagnostic and treatment considerations for women with cutaneous hyperandrogenism, noting therapeutic options are more effective for hirsutism and acne than for androgenetic alopecia, but reports no new clinical results.
33 citations
,
April 2015 in “Cochrane library” This review examined various treatments for hirsutism and found low to very low quality evidence suggesting that flutamide and spironolactone may help reduce hair growth, while metformin was ineffective.
30 citations
,
February 2016 in “British journal of dermatology/British journal of dermatology, Supplement” This review found moderate to very low-quality evidence that spironolactone, flutamide, and cyproterone acetate combined with oral contraceptives may reduce hirsutism more effectively than placebo or metformin, though results vary among other treatments.
25 citations
,
December 2017 in “The Journal of Clinical Endocrinology & Metabolism” This study found that using an oral contraceptive with bicalutamide significantly reduced hirsutism in women with PCOS compared to an oral contraceptive alone, although it increased total cholesterol and LDL levels.
19 citations
,
March 2018 in “JAMA” This guideline discusses the evaluation and treatment of hirsutism in premenopausal women, recommending oral contraceptive pills or antiandrogens as initial therapies with weak support from low-quality evidence.
19 citations
,
January 2013 in “Pediatrics in review” This review discusses the onset of menstruation and related challenges in young women, with a focus on primary amenorrhea, its diagnosis, and management strategies, and reports no new clinical findings.
14 citations
,
September 2015 in “Expert Opinion on Therapeutic Targets” This review discusses potential treatments for androgen excess in polycystic ovary syndrome and reports no new findings, emphasizing the importance of individualized antiandrogenic management to minimize side effects.
10 citations
,
January 2019 in “The Nurse Practitioner” This article reviews diagnostic and treatment guidelines for polycystic ovary syndrome, discussing how nurse practitioners can enhance patients' quality of life through education; it reports no new clinical results.
6 citations
,
May 2024 in “PLoS ONE” In this study, content analysis of German YouTube videos revealed that women frequently experience both positive and negative symptoms related to oral contraceptive use and discontinuation, with bodily sensations often influencing their decisions to start or stop the pill.
6 citations
,
November 2015 in “JAMA” This study found that oral contraceptive pills improve mild hirsutism, while flutamide and spironolactone are beneficial for more severe cases, but other therapies show inconsistent or no benefit.
3 citations
,
May 2021 in “PloS one” This study found that Jordanian males use oral contraceptive pills, particularly for bodybuilding, based on recommendations from gym coaches, highlighting unexpected uses of these medications.
3 citations
,
July 2011 in “Expert Review of Dermatology” This article reviews the causes and treatments of hirsutism, emphasizing the importance of considering ethnic and cultural norms when interpreting grading systems, and reports no new original findings.
1 citations
,
July 2006 in “Reviews in gynaecological and perinatal practice” This review explores various therapeutic options for managing female hirsutism, emphasizing the effectiveness of low-dose finasteride and cyproterone acetate, but it presents no new clinical results.
1 citations
,
February 2024 in “Gynecological Endocrinology” This study found that cyclic MPA is as effective as OCPs in resuming ovulation among women with PCOS, offering a viable alternative for those who cannot or choose not to use OCPs.
1 citations
,
December 2023 in “Environmental pollution” This study quantified around 60 organic pollutants in hair samples from mothers and infants in Spain, finding significant correlations between pollutant levels and factors like residence, dietary habits, and maternal age, with common exposure sources identified for several pollutant classes.
1 citations
,
March 2021 in “medRxiv (Cold Spring Harbor Laboratory)” This study provided insight into unexpected uses and abuse of oral contraceptive pills by Jordanian males, primarily for bodybuilding, as reported by community pharmacists.
1 citations
,
August 2013 in “Springer eBooks” Birth control pills and anti-androgen medications help manage hair growth, acne, and hair loss in women with PCOS.
1 citations
,
January 2002 in “Dermatology + psychosomatics” In this study, 90% of patients preoccupied with hair loss were found to have underlying affective disorders like depression, anxiety, OCD, or OCPD.
November 2025 in “International Journal of Research in Medical Sciences” This study observed that diffuse alopecia is the most common type of non-cicatricial alopecia in females and is significantly associated with connective tissue diseases, use of certain medications, and lower blood hemoglobin levels.
August 2023 in “International journal of reproduction, contraception, obstetrics and gynecology” This study found that combining letrozole with metformin was more effective at inducing pregnancy in women with PCOS compared to letrozole alone, while OCP and metformin significantly improved menstrual regularity and reduced hyperandrogenic symptoms.
April 2023 in “Expert opinion on pharmacotherapy” This review article concluded that combined oral contraceptive pills and antiandrogens are the most effective pharmacotherapy for improving hirsutism, while physical therapies and psychological support are essential for optimal management.
April 2019 in “Journal of Investigative Dermatology” This study suggests that hormone replacement therapy and oral contraception may have a protective role in scarring alopecia, as these were reported less frequently by patients with the condition compared to those with female pattern hair loss.