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Apple polyphenol, especially oligomeric procyanidins, can reduce fat absorption and lower blood fat levels.

Women with PCOS often have more belly fat and higher insulin levels, but belly fat isn't the only cause of their insulin resistance.

DHEA affects multiple receptors and may help with metabolic issues, but its safety and effectiveness in humans are unclear.

Melatonin helps regulate sleep and may aid in treating various health issues.

New treatments for PCOS show promise, including both medication and non-medication options.

Epidermal Wnt/β-catenin signaling controls fat cell formation and hair growth.

Women with PCOS and higher androgen levels are more likely to have fatty liver disease.

FGF signaling is a promising target for developing treatments for wounds, metabolic diseases, and cancer.

The definition of Polycystic Ovary Syndrome may change with new research, and careful screening is key for managing the condition.

The document concludes that accurate diagnosis and personalized treatment are important for skin problems in women with PCOS.

Skin fat helps with body temperature control and has other active roles in health.

The conclusion is that early diagnosis and a multi-system treatment approach are crucial for managing PCOS and its associated health risks.

Eating 500 fewer calories a day and making lifestyle changes can improve PCOS symptoms and reduce diabetes risk; more research is needed on its causes and treatments.

Women with PCOS often have skin problems like excessive hair, acne, hair loss, and dark patches, which can be treated with hormonal and non-hormonal therapies.

Certain medications including flutamide, spironolactone, and others effectively reduce excessive hair growth in women, especially when combined with lifestyle changes.

Hidradenitis suppurativa is a skin condition possibly caused by hair follicle issues, with treatments focusing on infection and inflammation.

SCD1 is crucial for skin health and overall energy balance.

Skin fat has important roles in hair growth, skin repair, immune defense, and aging, and could be targeted for skin and hair treatments.

Polycystic Ovary Syndrome is linked to higher risk of hypertension and heart disease.

Obese women with PCOS show a male-like pattern in certain fat tissue gene expressions.

To diagnose Polycystic Ovarian Syndrome, two out of three signs—irregular periods, high male hormone levels, or cysts on the ovaries—are needed.

Insulin resistance might not be enough to worsen blood vessel function in young, nonobese women with polycystic ovary syndrome.

Women with PCOS have similar levels of certain proteins compared to women without PCOS, and these proteins don't independently cause PCOS.

Certain genetic variations in the SHBG gene are linked to an increased or decreased risk of PCOS in Mediterranean women.

Lean and obese women with PCOS have similar levels of insulin resistance, indicating it's a core aspect of the condition.

Weight loss and metformin don't significantly change vaspin levels in women with PCOS.

Androgen is important in controlling stem cell differentiation, reducing fat development, and increasing lean mass.

A male with aromatase deficiency improved bone health with estradiol treatment.

The document concludes that Hidradenitis suppurativa is often underdiagnosed, lacks definitive treatment, and requires better awareness and management strategies.

Existing drug dexamethasone may lower death risk in severe COVID-19 cases; more research needed for other drugs.