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Drug repositioning is becoming more targeted and efficient with new technologies, offering personalized treatment options and growing interest in the field.

Genotyping for NUDT15 p.Arg139Cys can help predict thiopurine side effects in Japanese IBD patients.

Gene therapy has potential as a future treatment for Hutchinson-Gilford progeria syndrome.

The study developed a tool to predict how gut microbes process foods and drugs, showing that similar compounds often share metabolic pathways and effects.

Food deprivation increases MST enzyme in the brain, possibly affecting energy balance.

Fibroblasts, cells usually linked to tissue repair, also help regenerate various organs and their ability decreases with age. Turning adult fibroblasts back to a younger state could be a new treatment approach.

Skin and hair can help us understand organ regeneration, especially how certain stem cells might be used to form new organs.

Behçet's Disease may be caused by genetic and environmental factors leading to abnormal immune responses, and stress management and new treatments could improve patient outcomes.

Ion-paired risedronate significantly increases skin penetration without irritation compared to risedronate alone.

ALA-PDT is effective and safe for chronic X-ray dermatitis, providing complete or partial remission.

Ziziphus jujuba Mills may have health benefits, but more research is needed to confirm its safety and effectiveness.

Patients with Alopecia areata have fewer specific immune cells that normally regulate the immune system, which may contribute to the condition.

Acanthosis nigricans is a skin condition that may indicate a higher risk for insulin resistance and type 2 diabetes, and more research is needed to understand and treat it.

The new lab-grown skin model is good for testing sunscreen's protection against DNA damage from UV light.

ICL is a condition with low CD4+ T cells like AIDS but not caused by HIV, and normal CD4+ T cell counts may vary between men and women.

New gene identification techniques have improved the understanding and classification of inherited hair disorders.

Intralesional therapy for keratoacanthoma is effective and has fewer side effects than systemic treatments.

Particle properties affect drug retention and release in minoxidil foams, with lipid nanoparticles having higher loading capacity.

ATP increases melanin production in skin after UV exposure, with the P2X7 receptor being crucial for this process.

Insulin or IGF-I is needed for hair growth in newborn mice, while minoxidil helps adult mouse hair grow, suggesting a way to study human hair loss.

Gemcitabine and paclitaxel are effective and safe as first-line treatment for metastatic breast cancer.

Liposomes show promise in cancer treatment by delivering drugs with less toxicity and improved effectiveness.

Some drugs can cause skin and hair color changes, often reversible when the drug is stopped.

Tamoxifen can cause total hair loss but its benefits outweigh this side effect.

Spironolactone, a heart and liver drug, has new uses including cancer treatment, viral infection prevention, and skin condition improvement.

Annurca apple extract promotes hair growth by changing hair follicle metabolism to boost keratin production.

Polydeoxyribonucleotide (PDRN) may help lighten skin and treat hyperpigmentation.

Children with HIV often have skin problems that can indicate the severity of their immune system damage.

Some new isatin compounds could be strong cancer-fighting drugs because they fit well in cancer-related proteins and have good drug-like properties.

Lupus treatment requires a combination of drugs and therapies, with research needed for new options.