Idiopathic CD4+ T-Lymphocytopenia

    September 1992 in “ The Lancet ”
    Vincent Soriano, Indira Hewlett, Alonso Heredia, José Pedreira, Maria Gaby Rivero de Gutiérrez, R. Bravo, A. Castro, Juan González-Lahoz, Richard Kaczmarski, Ghulam J. Mufti, Struan K. Sutherland, Galal E. Yousef, F. W. Davison, John Moxham, E. Gane, Roger W. Williams, Stanley H. Weiss, CarolWeston Klein, RaghavanK. Mayur, James Besra, T. Denny, Siraj Misbah, H Chapel, Jeffrey Laurence
    Image of study
    TLDR ICL is a condition with low CD4+ T cells like AIDS but not caused by HIV, and normal CD4+ T cell counts may vary between men and women.
    The document from 1992 discusses idiopathic CD4+ T-lymphocytopenia (ICL), a condition characterized by low CD4+ T cell counts similar to AIDS but without HIV infection. The authors suggest that a persistent decrease in CD4+ T cells, confirmed by at least two counts taken more than 6 months apart, is crucial for diagnosing ICL. They also consider common variable immunodeficiency (CVI) as a differential diagnosis for HIV-negative patients with opportunistic infections and hypogammaglobulinaemia. In a study of 965 intravenous drug users, they found an average CD4 cell count of 1169/μl among 180 HIV-seronegative individuals, with no significant correlation with gender, age, race, or HTLV-II infection. Additionally, they observed that the CD4/CD8 ratio was higher in women than in men, indicating that normal immunological values might differ between genders.
    Discuss this study in the Community →