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The guideline suggests using specific criteria to diagnose PCOS, recommends various treatments for its symptoms, and advises screening for related health issues.

The document concludes that PCOS is a complex disorder caused by both genetic and environmental factors, affecting women's health in various ways, and requires personalized treatment.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Testosterone therapy improves physical function, strength, and body composition in older men with low testosterone levels.

Testosterone is important for men's sexual function, may help some women's sexual desire, while other hormones and neurotransmitters also play complex roles in sexual behavior.

The skin has a complex immune system that is essential for protection and healing, requiring more research for better wound treatment.

Manage vitiligo with treatments, address emotions, and use camouflage techniques.

Chemotherapy can cause various skin reactions, with hair loss being the most common, and proper diagnosis and treatment of these reactions are important.

Vitamin D receptor interacts with certain dietary components to help prevent diseases and regulate hair growth.

Noggin is necessary to start the hair growth phase in skin after birth.

Alopecia areata is likely an autoimmune disease with unclear triggers, involving various immune cells and molecules, and currently has no cure.

Jumonji genes are important for development and their mutations can cause abnormalities, especially in the heart and brain.

Hormone treatments in transsexual individuals reduce hair growth and oil production in male-to-females and increase them in female-to-males.

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

EGFR inhibitors often cause skin problems and other side effects, but these are usually reversible and can be managed to keep patients comfortable.

Foxp3 is crucial for regulatory T cell function, and targeting these cells may help treat immune disorders.

Finasteride effectively treats baldness but may cause sexual side effects.

Janus kinase inhibitors are promising treatments for autoimmune skin diseases like eczema and psoriasis.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

No single treatment is consistently effective for alopecia areata, and more research is needed.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

Hair loss linked to higher heart disease risk in both men and women.

Inhibiting 5α-reductase can help reduce prostate cancer risk and improve treatment.

Lampreys have a functional vitamin D receptor that may help detoxify harmful substances.

Cystatin M/E strongly inhibits cathepsin V and cathepsin L, important for skin formation.

Mutant CDP/Cux protein causes hair defects and reduced male fertility in mice.

Hair elemental analysis could be useful for health and exposure assessment but requires more standardization and research.

Microneedling is a safe and effective treatment for various skin conditions, often preferred for its fewer side effects and shorter recovery time.

Testosterone supplements can increase muscle mass and strength in older men with low levels, but long-term effects and risks need more research.

BMP2 and BMP7 have opposite roles in feather formation.