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In this study, researchers found that the naked (N) gene in mice indirectly affects the synthesis of structural proteins in mouse hair, resulting in reduced high tyrosine protein content and unusual amino acid compositions.

This letter to the editor raises concerns about minoxidil, an arterial vasodilator also used for androgenic alopecia, noting that overdose can cause severe side effects such as distributive shock, pulmonary edema, and myocardial ischemia.

This study found that the alkaloids cepharanthine and berbamine bind to SK2 and SK3 channel subtypes with affinities that match their concentrations active against various diseases, prompting further investigation into SK channels' role in their therapeutic effects.

This study found that microwave-assisted extraction significantly increased the yield of secondary metabolites, including phenolic and flavonoid content, from Nardostachys jatamansi, enhancing its anti-Alzheimer's potential compared to conventional extraction methods.

Minoxidil reacts to nitrosation 7 times more than phenol, mainly due to its -NH₂ groups, leading to the creation of N-nitrosominoxidil.

This case report identified a 4-month-old boy with Menkes disease, a neurodegenerative disorder of copper metabolism, noting symptoms like recurrent seizures, developmental delay, and specific physical characteristics, confirmed by genetic sequencing showing a pathogenic ATP7A mutation and low serum copper and ceruloplasmin levels.

This publication presents a library of precision geometric medicines that reportedly kill harmful bacteria and fungi while sparing beneficial organisms, using a delivery system that targets pathogens specifically and avoids ecological harm.

This review compiles current research on the role of long non-coding RNAs in regulating muscle growth and regeneration processes, particularly their influence on Duchenne muscular dystrophy, and reports no new clinical results.

In this study, finasteride increased cardiac damage but reduced mutagenic effects in male rats treated with anabolic steroid ND, suggesting variable organ-specific responses to metabolic inhibition.

This case study of a 2-month-old boy with maple syrup urine disease highlights the dangers of restricting branched-chain amino acid intake, as it led to acrodermatitis dysmetabolica-like skin eruptions and hair loss, later resolved with careful dietary adjustments and monitoring.

This study found that neither caffeine nor N,N-dimethylglycine treatments were toxic to balding or nonbalding dermal papilla cells and could stimulate calcium influx, indicating treatment responsiveness.

Chitosan-coated nanocapsules improve minoxidil delivery for better hair regrowth.

This study developed a novel, 3D-printed dissolving microneedle system for delivering minoxidil to treat hair loss, which showed pH-triggered drug release and enhanced hair regrowth in an alopecia mouse model, offering a potentially sustainable and safe transdermal therapy option.

This research observed that the skeletal abnormalities in Noggin null mice varied based on genetic background, and identified haploinsufficiency leading to joint fusions, similar to human conditions associated with NOGGIN deficiency.

This study by Pérez-Oliva et al. explored how Mahogunin Ring Finger-1 (MGRN1) affects melanocortin-1 receptor (MC1R) signaling, suggesting that MGRN1 competitively inhibits Gαs binding to MC1R, influencing pigment production.

This study identified a heterozygous de novo mutation in the ODC1 gene causing a new disorder characterized by overgrowth and developmental delay, and suggests that DFMO treatment may help manage elevated ODC activity and putrescine levels.

This study concluded that male mice are more susceptible to valproic acid-induced autism spectrum disorder than female mice, with noticeable differences in brain histoarchitecture and receptor protein levels.

This study formulated a minoxidil nanoemulgel with improved solubilization and skin penetration, demonstrating a high entrapment efficiency and sustained drug release in vitro, which suggests potential improvements in treating androgenetic alopecia compared to conventional formulations.

This study reported that a novel vasodilator drug called TOP-M119, when delivered using a specially designed dissolving microneedle system, showed enhanced targeting of hair follicles and effectiveness in treating alopecia, demonstrated through in vitro, ex vivo, and in vivo studies involving mouse skin.

This study found that a microneedle patch using manganese thiophosphite showed greater hair regrowth potential compared to minoxidil, even with less frequent application, for treating androgenetic alopecia.

This study found that androgen is essential for erectile function in rats, and suggests that its effects may be partly mediated through nitric oxide synthase positive neurons in the medial preoptic area.

This article discusses mnemonics in dermatology but reports no new clinical findings or results.

This study demonstrated that ablation of individual somatostatin-expressing interneurons increased activity in nearby neurons of the mouse motor cortex during motor learning.

In this thesis, researchers explored ways to enhance the management of myotonic dystrophy type 1 by investigating the genetic inheritance patterns, especially small-sized repeat expansions, and assessing cardiac care, energy expenditure, and body composition in affected individuals.

This study found that the E3 ligases NEDD4 and NEDD4L regulate intestinal stem cell priming by degrading the LGR5 receptor, and their loss leads to increased Wnt activation and crypt proliferation, which in turn accelerates intestinal tumor progression in mice.

In this animal study, agmatine exhibited a protective effect against seizures related to hormone fluctuations, with results suggesting that its anticonvulsant properties may involve interactions with central neurosteroids in female rats experiencing progesterone withdrawal.

This review reports that nirmatrelvir-ritonavir has significant drug-drug interactions with many common dermatological medications, whereas molnupiravir may be an alternative therapy due to the absence of such interactions observed so far.

Made 8 minoxidil samples; 1 cocrystal, 7 salts formed.

This study found that nanostructured lipid carriers provided better skin-targeted delivery and drug loading for lidocaine than nanoethosomes, indicating improved local anesthetic efficacy in vitro.