Finasteride Promotes Worsening of the Cardiac Deleterious Effects of Nandrolone Decanoate and Protects Against Genotoxic and Cytotoxic Damage

    January 2020 in “ Figshare ”
    Elizângela Faustino Da Mata, Andrews Marques do Nascimento, Ewelyne Miranda de Lima, Iêda Carneiro Kalil, Denise Coutinho Endringer, Dominik Lenz, Nazaré Souza Bissoli, Girlândia Alexandre Brasil, Tadeu Uggere de Andrade
    TLDR Finasteride worsens heart damage but reduces cell toxicity caused by nandrolone decanoate.
    The study investigated the effects of finasteride on the cardiac and mutagenic impacts of nandrolone decanoate (ND) in male Wistar rats. ND increased cardiac hypertrophy, ACE activity, and disrupted cytokine balance, and these effects were exacerbated by finasteride. However, finasteride reduced ND's toxic effects on bone marrow cells, normalizing the number of micronucleate polychromatic erythrocytes and the mitotic index. The findings indicated that ND's harmful effects were partly due to its metabolism, and finasteride had varying effects depending on the organ, worsening cardiac damage while reducing mutagenic effects.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community Nandrolone Replacement Therapy

      in Treatment  41 upvotes 1 year ago
      A user discusses starting nandrolone replacement therapy to stop hair loss and improve hair health, noting its benefits over finasteride. They report halted hair loss, improved skin, increased muscle, and a calm mood after three weeks.

      community Hair loss treatment rabbit hole [OC]

      in Satire  317 upvotes 2 years ago
      Hair loss treatments, ranging from topical minoxidil and finasteride to taking hormones such as estradiol or nandrolone, as well as a controversial suggestion of an orchiectomy. A hair system is also mentioned as an alternative solution.

      community What has helped you regrow your temples?

      in Chat  21 upvotes 1 year ago
      User seeks advice for regrowing temples, currently using Fin, oral Min, and dermarolling. Suggestions include improving scalp environment and considering RU58841 or dutasteride.

      community Is the DHT itch fact or fiction?

      in Chat  16 upvotes 1 year ago
      DHT itch's existence is debated, with some claiming it's real and others saying it's psychological. Finasteride, Ketoconazole shampoo, and addressing scalp conditions like dandruff or eczema may help reduce itchiness.

      community Dutasteride Vs. Testosterone, who wins?

      in Finasteride/Dutasteride  58 upvotes 5 months ago
      The conversation discusses whether 2.5mg of dutasteride or 200mg of testosterone weekly is more influential in preventing hair loss, with various personal experiences indicating that the effectiveness is dependent on the individual's genetic profile. Some users report that dutasteride is likely to be more effective at the given doses.

    Related Research

    7 / 7 results