62 citations
,
January 2004 in “PubMed” This review describes the shift in treating symptomatic benign prostatic hyperplasia from surgery to 5alpha-reductase inhibitor drugs, which may provide symptom relief and alter BPH's progression, but reports no new clinical results.
14 citations
,
January 2023 in “Engineered Regeneration” In this study, researchers highlighted the potential of antioxidative nanozymes as a promising treatment for ischemic stroke, due to their stability, cost-effectiveness, and ability to regulate ROS-induced inflammation, positioning them as a noteworthy alternative to natural enzymes like catalase and superoxide dismutase.
April 2020 in “Online journal of complementary & alternative medicine” This article discusses the FDA approval of bremelanotide for premenopausal women with hypoactive sexual desire disorder and reports no clinical results.
January 2018 in “journal of applied pharmaceutical science” This study found that biomimetic peptides may enhance the expression of growth factors in the hair follicles of patients experiencing telogen effluvium.
28 citations
,
September 2000 in “Journal of Medicinal Chemistry” This study identified novel compounds as selective inhibitors of the type 1 isoenzyme of 5α-reductase, displaying promising potential for treating DHT-dependent disorders such as acne and androgenic alopecia.
5 citations
,
January 2001 in “Advances in protein chemistry” This chapter reviews recent advances in 5α-reductase inhibitors for treating disorders mediated by dihydrotestosterone and reports no new clinical findings.
195 citations
,
February 2007 in “The Journal of Clinical Endocrinology and Metabolism” In this study, administering 5alpha-reductase inhibitors reduced dihydrotestosterone levels and was associated with mild, reversible decreases in semen parameters in healthy men.
January 2013 in “The Journal of Sexual Medicine” In a rat model, this study found that a hydrogel incorporating adipose-derived stem cells and nerve growth factor may aid in the recovery of erectile function following cavernous nerve injury.
20 citations
,
February 2002 in “Expert Opinion on Therapeutic Patents” This review discusses the potential uses of 5α-reductase inhibitors for conditions ranging from benign prostatic hyperplasia to skin disorders like acne and male pattern baldness, but it reports no new clinical results.
11 citations
,
June 2018 in “Sexual medicine reviews” This review evaluates existing preclinical and clinical studies on stromal vascular fraction for treating male sexual dysfunction, finding limited data and emphasizing the need for more research before conducting clinical trials.
October 2006 in “Urology” The study found that different criteria led to different patient groups in the CombAT study compared to the MTOPS study.
In this study, researchers reported that hardshell capsules using the DiluCap® line of excipients demonstrated varying dissolution profiles under gastrointestinal-simulating conditions, with minoxidil and finasteride showing rapid release and melatonin and naltrexone displaying controlled release, indicating their suitability for different applications in compounding pharmacies.
12 citations
,
March 2023 in “The FASEB Journal” This study found that platelet-rich plasma treatment significantly improved erectile function and restored neural structures in aged rats with erectile dysfunction, suggesting potential benefits for geriatric patients.
1 citations
,
April 1987 in “American Journal of Nursing” Some drugs can cause serious side effects, like hypoglycemia from mix-ups, skin reactions, or depression, and while penicillamine may help rheumatoid arthritis more than auranofin, it has more severe side effects.
9 citations
,
July 2011 in “The Journal of Sexual Medicine” This article examines 5 alpha-reductase inhibitors and their link to persistent sexual dysfunction, but it reports no new clinical findings.
2 citations
,
January 2011 in “Clinical medicine insights” The authors concluded that dutasteride is effective and generally safe for managing benign prostatic hyperplasia and may reduce prostate cancer risk.
123 citations
,
January 2012 in “The Keio Journal of Medicine” This review discusses anti-angiogenic therapy for cancer, highlighting VEGF blockers' effectiveness but also their limitations, such as resistance and adverse effects; it reports no new clinical results.
12 citations
,
December 2015 in “F1000Research” This article discusses advancements and future directions in the treatment of benign prostatic hyperplasia, highlighting ongoing clinical trials of novel techniques, but it reports no new clinical results.
March 2021 in “CRC Press eBooks” This review discusses the application of mesotherapy in dermatology and trichology, noting its potential benefits and issues, but reports no new clinical results.
2 citations
,
March 1985 in “Journal of The American Academy of Dermatology” Minoxidil solution used on the scalp did not lower blood pressure in patients without hypertension.
13 citations
,
December 2012 in “Frontiers in bioscience” This review discusses the potential role of vitamin D deficiency in cardiovascular and renal diseases and suggests that supplemental vitamin D could benefit cardiovascular outcomes, especially in African American and postmenopausal women; it reports no new clinical findings.
11 citations
,
May 1990 in “Journal of Dermatological Science” In this animal study, topical diazoxide treatment led to increased hair thickness and follicle growth in bald stumptailed macaques without causing notable systemic side effects.
April 2017 in “Actas urológicas españolas” This review analyzes existing literature on prognostic factors for renal cell carcinoma, highlighting the need for continuous updates of prognostic models to reflect advancement in molecular pathway knowledge and targeted therapies.
8 citations
,
January 2025 in “Gels” This study developed cilostazol-loaded formulations for nose-to-brain delivery, finding that these formulations improved cilostazol's bioavailability by enhancing solubility, absorption, and permeability, achieving nearly 100% drug release in vitro within 2 hours.
7 citations
,
August 1996 in “The Journal of Clinical Endocrinology and Metabolism”
June 2018 in “The Journal of Sexual Medicine” Low-intensity shock wave therapy is effective in treating erectile dysfunction in diabetic patients.
13 citations
,
February 2020 in “CHEST Journal” This case report observed that pulmonary arterial hypertension in a man with severe vitamin C deficiency resolved after vitamin C supplementation, suggesting a potential role of vitamin C in managing this condition.
December 2024 in “International Journal of Drug Delivery Technology” This study reports that a novel Nano-Structured Lipid Carrier system for delivering dutasteride may enhance its anticancer effects while reducing systemic side effects in clinical settings.
2 citations
,
November 2019 in “Current Geriatrics Reports” Tailored treatment is crucial for elderly men with BPH due to potential risks and benefits of medications.
6 citations
,
January 2016 in “Bioorganic & Medicinal Chemistry Letters” This study reported that certain minoxidil conjugates, specifically those with spermine, methylenedianiline, and diaminofluorene, were able to induce differentiation in HL-60 acute myeloid leukemia cells without toxicity at a concentration of 10 μM.