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The Rotterdam Study investigates diseases in older adults and has produced many research findings.

Finasteride effectively treats BPH but may increase sexual dysfunction risk.

Method detects finasteride in plasma at very low concentrations.

VEGF helps hair grow and determines follicle size by increasing blood vessel growth.

Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.

Hair cortisol levels can show increased stress during late pregnancy but only for up to six months.

Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.

Coumarin derivatives show promise as anti-estrogenic agents for treating breast cancer, with some in clinical trials.

Improving artificial vascular grafts requires better materials and surface designs to reduce blood clotting and support blood vessel cell growth.

Hair and nail cells share similar proteins, indicating a common differentiation pathway.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

Anticancer drugs are increasingly found in surface waters, and their long-term environmental effects are not well understood, requiring better testing methods.

TRPA1 is crucial for mechanical sensitivity in skin sensory neurons.

The skin's layers protect, sense, and regulate the body's internal balance, but can be prone to cancer.

Chemotherapy can cause various skin reactions, with hair loss being the most common, and proper diagnosis and treatment of these reactions are important.

The research shows that a gene called Wnt3 affects hair growth and structure, causing short hair and balding when overactive.

The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

Melatonin in the skin helps protect against damage from stress and UV rays, and could be used to treat certain skin conditions.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.

The timing of when the gene Bmal1 is active affects aging and survival, with its absence during development, not adulthood, leading to premature aging.

The Rotterdam Study aims to understand various diseases in older adults.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Noggin is necessary to start the hair growth phase in skin after birth.

Androgens can both increase and decrease hair growth in different parts of the body.

Interferon alfa-2a is effective for treating cutaneous T cell lymphoma but has significant side effects.

PGD2 stops hair growth and is higher in bald men with AGA.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.