February 2023 in “Indian journal of private psychiatry/Indian Journal of Private Psychiatry” This case report highlights a rare instance of fingernail and toenail hyperpigmentation following the use of valproic acid, which resolved after discontinuation of the drug.
December 2022 in “Gastroenterology” This report describes a case of Cronkhite-Canada syndrome diagnosed in a 54-year-old man with symptoms including gastrointestinal polyps, alopecia, skin hyperpigmentation, and severe diarrhea, who experienced significant symptom improvement with azathioprine.
This article reviews the history and characteristics of the rare nude phenotype SCID, primarily distinguished by severe T cell immunodeficiency and notable skin and hair abnormalities, but reports no new clinical findings.
May 2021 in “Research journal of topical and cosmetic sciences” In this study, oral supplementation of Microcore’s TrichovitalsTM significantly improved the appearance of facial skin, hair, and nails over 12 weeks in healthy middle-aged adults compared to a control group.
January 2020 in “Medpulse International Journal of Medicine” This study found that nail and hair changes were predominantly observed in patients with stage 5D chronic kidney disease, with the most common changes being half and half nails and sparse scalp hair.
November 2018 in “The European research journal” In this study, researchers found that patients with alopecia areata who had nail involvement or a history of autoimmune disease showed significantly higher red cell distribution width levels.
May 2018 in “Dermatologic Surgery” This overview details the Dermatologic Surgery journal's focus on various dermatologic surgical procedures, but it presents no new research findings.
March 2018 in “Gazi medical journal” This study found that adults with β-thalassemia major had a significantly higher prevalence of skin, hair, and nail disorders compared to healthy controls, influenced by factors like age, gender, and ferritin levels.
January 2015 in “Dermatology online journal” This case report reviews a 67-year-old man with both alopecia totalis and lichen planus of the nails, suggesting a possible autoimmune link between these rare concurrent conditions, but presents no new clinical data.
January 2014 in “Pathology” The document concludes that understanding nail anatomy is key for diagnosing nail diseases, early signs of nail melanoma may allow for less aggressive treatment, and specific genetic mutations are important in thyroid cancer prognosis and treatment.
This study found that polycystic ovary syndrome was the most common cause of hirsutism among premenopausal Algerian women.
This study found that polycystic ovary syndrome was the most common cause of hirsutism among premenopausal Algerian women, affecting nearly 60% of participants.
This study found that the nail immune system is similar to the hair follicle immune system, with both showing a relative "immune privilege" that may protect against autoimmunity.
44 citations
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May 1980 in “Archives of Dermatology” This case study discusses a patient with persistent 20-nail dystrophy following alopecia areata, suggesting that "20-nail dystrophy" describes a condition with multiple potential causes.
37 citations
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January 2005 in “Clinics in dermatology” This review discusses recent advances in understanding the genetics of hair and nail disorders and reports no new clinical results.
7 citations
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January 2017 in “Annals of Dermatology” This study found that among patients with twenty-nail dystrophy, those treated with oral cyclosporine in combination with a dietary supplement showed significantly better improvement in nail condition and quality of life than those treated with the supplement alone.
3 citations
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January 2019 in “Annals of dermatology/Annals of Dermatology” Hydroxychloroquine effectively treated twenty-nail dystrophy in a patient with alopecia areata.
2 citations
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June 2023 in “Clinical and Experimental Neuroimmunology” In this case study, the coexistence of thymoma-associated myasthenia gravis, alopecia areata, and twenty-nail dystrophy in a patient is reported, suggesting thymoma may increase the risk of developing these conditions.
February 2026 in “Indian Journal of Dermatology” This case report found that a 48-year-old woman with idiopathic twenty-nail dystrophy experienced significant improvement in nail appearance after six months of treatment with oral Upadacitinib.
November 2024 in “Journal of Investigative Dermatology” Genetic defects in the Wnt/PCP pathway may cause congenital yellow nail syndrome.
December 2021 in “Australasian Journal of Dermatology” This study reported cases of post-COVID-19 telogen effluvium in patients who also exhibited distinctive red band changes in their nails.
April 2019 in “International journal of research in dermatology” This case report describes a 6-year-old child with twenty nail dystrophy and alopecia areata of the scalp.
July 2018 in “British Journal of Dermatology” Hair regrowth was seen in 83% of children with alopecia, immune system plays a role in the condition, and various treatments showed effectiveness for hair and nail disorders.
April 2016 in “Journal of The American Academy of Dermatology” Dutasteride is more effective than finasteride for hair growth with similar side effects.
114 citations
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January 2007 in “Drug Safety” This review discusses various adverse drug reactions affecting the skin, hair, and nails, emphasizing the importance of recognizing and reporting these reactions but reports no new clinical findings.
36 citations
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December 1991 in “Journal of Dermatological Science” Human nails contain both skin and hair keratins, each needing different extraction methods.
33 citations
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April 2020 in “Dermatitis” This study found that 9% of tested patients had positive patch test reactions linked to hair care products, with most reactions clinically relevant and commonly involving allergens like p-phenylenediamine.
26 citations
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October 2016 in “Case Reports in Dermatology” In this study, tofacitinib treatment in a male patient with alopecia areata led to significant hair regrowth and improvement in nail dystrophy symptoms, restoring finger function within 10 months.
25 citations
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October 2017 in “Clinics in Dermatology” This review discusses common hair and nail diseases in the elderly and reports no new clinical results, noting their significant impact on quality of life.
18 citations
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March 1974 in “Acta dermato-venereologica” Chronic kidney disease can cause skin and nail problems.