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This review discusses the potential link between selenium supplementation and symptoms of chronic selenium toxicity, such as hair loss and nail dystrophy, due to excess intake leading to disruptions in hair and nail protein structure.

This study observed that taking 500mg/day of Microcore’s Muttaijow ComplexTM for 12 weeks significantly improved the appearance of skin, hair, and nails in healthy middle-aged adults.

This study observed that a combination of arginine silicate complex and magnesium biotinate significantly improved hair and nail growth in rats.

This study presented cases of severe and permanent nail changes resembling lichen planus in patients with chilblain lupus erythematosus, suggesting a unique pattern related to cold exposure rather than typical histopathology findings.

Patients with Focal Dermal Hypoplasia often experience skin, nail, hair, and bone issues, and may benefit from calcium and vitamin D supplements.

This study observed that nearly 70% of children with treatment-resistant alopecia areata had nail involvement, primarily pitting, and this was significantly associated with longer disease duration but not disease severity.

This study observed that nearly 70% of children with treatment-resistant alopecia areata had nail involvement, predominantly pitting, which was significantly linked to longer disease duration but not the severity of scalp hair loss.

This study observed that nearly 70% of children with treatment-resistant alopecia areata had nail involvement, and while this was associated with longer disease duration, it did not correlate with the severity of scalp hair loss.

This systematic review found that topical minoxidil significantly increases nail growth in healthy individuals and patients with nail disorders, showing a promising mean increase in growth rate and clinical response compared to controls, without serious adverse effects reported.

This systematic review found that topical minoxidil may safely enhance nail growth, with significant increases observed in healthy individuals and those with nail disorders, although larger trials are necessary to confirm its long-term efficacy.

This study found that activating BMP signaling in rodent and primate models significantly promotes nail and digit regeneration after amputation by enhancing the role of specific nail stem cells, though extreme proximal amputation only permitted partial regeneration without bone reconstruction.

In this study, nail involvement was observed in 42.8% of children with alopecia areata, yet often went unrecognized, indicating that clinical and dermoscopic evaluations can improve detection and provide important prognostic information.

This study developed a method using Convolutional Neural Networks to detect nutritional deficiencies, such as iron, zinc, biotin, and vitamins, through high-resolution images of hair and nails, achieving an 89% accuracy rate in identifying these deficiencies.

In this narrative review, researchers found preliminary evidence suggesting that minoxidil, both topical and oral, may enhance nail growth and improve nail strength and appearance, though more extensive studies are needed to confirm its efficacy and safety for this off-label use.

This study observed that 78.3% of patients with alopecia areata exhibited nail changes detectable by dermoscopy, notably nail pitting, in contrast to 14.2% of healthy controls, with these changes significantly associated with disease severity, age, and duration.

This case report describes a father with HOXC13-associated pure hair-nail ectodermal dysplasia, presenting with severe nail dystrophy affecting all digits and notable hypotrichosis or complete alopecia.

In this randomized, placebo-controlled study, Titagen® was found to improve skin, hair, and nail health in adults consuming 5g daily, and reduce pain and improve quality of life for osteoarthritis patients taking 10g daily, without related adverse events.

In this clinical trial, the researchers observed that a biotin and silica supplement reduced hair fall, increased hair growth rate, and improved skin elasticity, hydration, and nail quality over 90 days without adverse effects.

Minoxidil may improve nail growth and appearance.

Systemic therapies improve nail psoriasis but have high side effects; more research is needed.

In this study, nail changes, particularly pitting, were associated with moderate to severe cases of alopecia areata and a positive family history, highlighting potential genetic factors in the condition.

Tildrakizumab significantly improved psoriasis symptoms and well-being over 52 weeks.

This case report outlines a 10-year-old boy who experienced a six-year history of twenty-nail dystrophy, highlighting the importance of physical examination for early diagnosis and management of nail disorders, with his primary symptoms involving nail disfigurement and alopecia areata, but no other health issues.

Nail color change might be an early sign of skin pigmentation from minocycline.

This study highlights the use of hair and fingernail cortisol levels as retrospective indicators of chronic stress, particularly in minoritized populations facing social stressors that increase the risk of mental health issues.

This report details a case of hair, nail, and pigmentary disorders occurring 10 months after starting abemaciclib for metastatic breast cancer, highlighting that cutaneous side effects, although less frequent, can lead to discontinuation in 25% of cases.

In this case report, a patient with alopecia areata-associated nail changes experienced normalization of nail appearance and texture after 11 months of treatment with baricitinib, suggesting that the drug may be an effective option for similar cases, although further research is needed.

This chapter provides an overview of 11 common hair and nail conditions in children with brown skin, utilizing clinical photographs and a question-and-answer format to discuss conditions such as alopecia areata, telogen effluvium, and nail lichen planus.

This study concluded that topical minoxidil could effectively accelerate nail growth in both healthy individuals and those with nail disorders, though the regimen might differ across these groups.

In this case study, a 12-year-old boy with isolated nail lichen planus showed significant improvement after receiving intramuscular triamcinolone acetonide and topical tacrolimus treatment, although his great toenails were less responsive.