Therapeutic Efficacy of Combination Therapy Using Oral Cyclosporine with a Dietary Supplement (Pantogar) in Twenty-Nail Dystrophy
January 2017
in “
Annals of Dermatology
”
Studysummary This study found that among patients with twenty-nail dystrophy, those treated with oral cyclosporine in combination with a dietary supplement showed significantly better improvement in nail condition and quality of life than those treated with the supplement alone.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The study assessed the effectiveness of combining oral cyclosporine with the dietary supplement Pantogar® in treating twenty-nail dystrophy (TND) in 82 patients. The combination therapy group, consisting of 38 patients, showed significantly better outcomes than the 44 patients treated with Pantogar® alone. Specifically, 13.2% of the cyclosporine group achieved almost clear nail plates, and their mean CHATS score decreased by 13.45, compared to an 8-point decrease in the control group (p<0.001). Additionally, the cyclosporine group experienced greater improvements in the Dermatology Life Quality Index (DLQI), indicating enhanced quality of life. Mild gastrointestinal side effects were noted in 10.53% of the cyclosporine group. The study concluded that oral cyclosporine was an effective treatment for TND, though it highlighted the need for larger, randomized controlled trials to confirm these findings.
