research Hirsutism
Hirsutism is excessive male-pattern hair growth in women, often treated cosmetically or with hormone therapy if contraception is also desired.
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540-570 / 1000+ resultsresearch Finasteride Inhibits Epinephrine Synthesis in Humans: Implications for Sexual Dysfunction
Finasteride may cause sexual dysfunction by reducing epinephrine levels.
research Association Between Degrees of Alopecia and Prostate Specific Antigen Level in Men With Androgenetic Alopecia
No link found between hair loss severity and PSA levels in men.
research Spermidine/Spermine-N1-Acetyltransferase: A Key Metabolic Regulator
Spermidine/spermine-N(1)-acetyltransferase (SSAT) was identified as a crucial enzyme regulating cellular polyamine content, impacting normal and neoplastic growth, ion channel regulation, and potentially cancer chemotherapy. SSAT activity was highly regulated and could be induced by various stimuli, affecting polyamine homeostasis and linking polyamine metabolism to lipid and carbohydrate metabolism. Increased SSAT activity led to a futile cycle consuming ATP and acetyl-CoA, and was associated with adverse effects such as pancreatic cell death, tissue growth blockage, behavioral changes, and hair loss. SSAT also interacted with proteins like hypoxia-inducible factor-1 alpha and NF-kappaB, though the exact mechanisms were unclear. While SSAT was considered a potential target for diseases beyond cancer, its broad physiological effects necessitated careful targeting to avoid toxicity.
research Glycome Profiling by Lectin Microarray Reveals Dynamic Glycan Alterations During Epidermal Stem Cell Aging
Aging changes sugar molecules on skin stem cells, which may affect their ability to repair skin.
research Effects of a New Topical Treatment Containing Several Hair Growth Promoters in Women with Early Female Pattern Hair Loss
New treatment reduces hair shedding and increases hair density in women with early hair loss.
research Rice Derivatives in Hair Protection
Rice derivatives in conditioners protect and improve hair health.
research Using the Frog Embryonic Epidermis as a Model to Study Desmosome Function During Development
Frog skin cells need the protein desmoplakin for proper development and cell layer formation.
research Comparative Analysis of Treatment Methods for Androgenetic Alopecia Using a Combination of Zinc Hyaluronate Gel and Physical Factors
Combining zinc hyaluronate electroporation with photostimulating therapy is more effective for treating hair loss in men and women.
research Faculty Opinions Recommendation of Thymic Peptides Differentially Modulate Human Hair Follicle Growth
Thymic peptides can either promote or inhibit human hair growth.
research Expression Patterns of MITF During Human Cutaneous Embryogenesis: Evidence for Bulge Epithelial Expression and Persistence of Dermal Melanoblasts
Melanocyte precursors in human fetal skin follow a specific migration pattern and some remain in the skin's deeper layers.
research Efficacy of Metformin Therapy in Adolescent Girls with Androgen Excess: Relation to Sex Hormone-Binding Globulin and Androgen Receptor Polymorphisms
Metformin works better for adolescent girls with PCOS who have certain genetic variations.
research New Approach to 3-Oxo-4-Aza-5α-Androst-1-Ene-17β-(N-Tert-Butylcarboxamide)
A new method was developed to make finasteride for treating hair loss.
research Minoxidil Topical Treatment May Be More Efficient If Applied on Damp Scalp Compared to Dry Scalp
Minoxidil works better when applied on a damp scalp than a dry one.
research Effect of Melatonin Supplementation from Mid to Late Gestation on Hair Growth and Skin Temperature of Beef Cattle
Melatonin supplementation may lower skin temperature in unshaved areas of pregnant beef cattle.
research Consumption of a Low-Carbohydrate and High-Fat Diet Exaggerates Biotin Deficiency in Mice
The ketogenic diet can worsen biotin deficiency, suggesting a need for biotin supplements.
research Inhibition of 5α-Reductase Alters Pregnane Metabolism in the Late Pregnant Mare
Inhibiting 5α-reductase increases progesterone levels in late pregnant mares.
research Preparation and Evaluation of Hair Growth Formulations of Indian Ginseng (Withania Somnifera) for Alopecia
Indian Ginseng may help promote hair growth for treating alopecia.
research Psycho-Emotional Conditions in Patients with Non-Scarring Alopecia (Circumscribed, Androgenetic)
Patients with non-scarring hair loss often have emotional disorders.
research A Biochemical Marker In A Dominant Mouse Trait
The study investigated the biochemical differences in hair between mice heterozygous for the Naked (N) trait and normal mice. It found that the mutant hair had significantly lower levels of glycine and tyrosine, with 20% less glycine and 27% less tyrosine compared to normal hair. Further analysis showed that proteins extracted from Nn hair contained 30% less glycine and 40% less tyrosine. These findings indicated that the Nn hair was deficient in a specific protein fraction rich in glycine and tyrosine, which comprised about 25% of the total protein in mouse hair. This mutation served as a biochemical marker for a dominantly inherited trait.
research Hair Growth-Promoting Activity of Hot Water Extract of Thuja Orientalis
Thuja orientalis hot water extract may help hair grow by starting the growth phase and improving hair follicle development.
research The Role of Patients in Alopecia Areata Endpoint Development: Understanding Physical Signs and Symptoms
The main goal for new Alopecia Areata treatments should be significant improvement in scalp hair growth.
research Psycho-Emotional Conditions of Patients with Non-Scarring Alopecia (Circumscribed, Androgenetic)
Patients with non-scarring alopecia often experience emotional disorders like depression and stress.
research Irregular Menstruation, Acne, Hirsutism, and the Possibility of PCOS
Women with irregular periods should be checked for PCOS and treated early to prevent complications, with birth control pills helping to manage symptoms.
research Synthesis and Structure–Activity Relationships of the First Ferrocenyl-Aryl-Hydantoin Derivatives of the Nonsteroidal Antiandrogen Nilutamide
Scientists made the first metal-based compounds from a nonsteroidal antiandrogen drug, which showed potential in fighting both hormone-dependent and independent prostate cancer cells.
research Relationships Between Cerebrospinal Fluid GABAergic Neurosteroid Levels and Symptom Severity in Men with PTSD
Lower levels of certain brain chemicals are linked to worse PTSD symptoms in men.
research Effect of Constant-Release Melatonin Implants and Prolonged Exposure to a Long Day Photoperiod on Prolactin Secretion and Hair Growth in Mouflon (Ovis Gmelini Musimon)
Melatonin implants and long daylight hours alter the timing of hormone release and hair growth in mouflon sheep.
research Template-Directed Self-Assembly and Growth of Insulin Amyloid Fibrils
A new method speeds up insulin amyloid fibril growth, useful for studying diseases.
research Incomplete Recovery of Erectile Function in Rats After Discontinuation of Dual 5-Alpha Reductase Inhibitor Therapy
Rats had lasting erectile problems after stopping a certain medication.
research Transforming Growth Factor-β, Smad, and Collagen Expression Patterns in Fetal and Adult Keratinocytes
Keratinocytes show more TGF-β system activity and collagen production as they age, which might affect wound scarring.