The Role of Patients in Alopecia Areata Endpoint Development: Understanding Physical Signs and Symptoms

October 2020 in “ Journal of Investigative Dermatology Symposium Proceedings ”

Kathleen W. Wyrwich, Helen Kitchen, SL Knight, Natalie Aldhouse, Jake Macey, Fabio P. Nunes, Yves Dutronc, Natasha Atanaskova Mesinkovska, Justin Ko, Brett King

alopecia areata scalp hair loss eyebrow hair loss eyelash hair loss nose hair loss body hair loss facial hair loss eye irritation nail damage autoimmune disease AA

TLDR The main goal for new Alopecia Areata treatments should be significant improvement in scalp hair growth.

The study titled "The Role of Patients in Alopecia Areata Endpoint Development: Understanding Physical Signs and Symptoms" conducted 30 semistructured interviews with adult (n = 25) and adolescent (n = 5) patients suffering from severe or very severe Alopecia Areata (AA), a chronic autoimmune disease causing hair loss. The study found that scalp hair loss was the most significant symptom for 90% of the patients, with 77% (n = 23) naming it as the most bothersome. Other bothersome symptoms included eyebrow, eyelash, nose, body, and facial hair loss, as well as eye irritation and nail damage. The study concluded that the primary objective for new AA treatments should be meaningful improvement in scalp hair growth.

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Research cited in this study

2 / 2 results

research The Autoimmune Basis of Alopecia Areata: A Comprehensive Review

162 citations, October 2014 in “Autoimmunity reviews”

Alopecia areata is caused by the immune system attacking hair follicles.

research Alopecia Areata: An Evidence-Based Treatment Update

72 citations, July 2014 in “American journal of clinical dermatology”

Some treatments, like corticosteroids and sensitizing agents, can help with alopecia areata, but more high-quality research is needed.

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The post discusses the theory that persistent dandruff in areas prone to hair loss could be a sign of hair follicles dying due to DHT, indicating balding. The responses vary, with some users noting improvements in dandruff and hair loss with treatments like Dutasteride, while others experienced hair loss without dandruff.

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Related Research

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research Oral Tofacitinib: A Promising Treatment in Atopic Dermatitis, Alopecia Areata, and Vitiligo

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