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Wnt signaling may be linked to heart diseases in aging and could be a target for future treatments.

The Wnt/β-catenin pathway is important for body functions and diseases, and targeting it may treat conditions like cancer, but with safety challenges.

Muscles can make their own androgens, which may help muscle growth.

COVID-19 may harm male fertility and damage the reproductive system.

The Wnt/β-catenin pathway helps tissue regeneration but can also cause fibrosis, and drugs that inhibit this pathway may aid in healing skin and heart tissues.

NF-κB is crucial for zebrafish heart repair, affecting heart cell growth and repair processes.

Fibroblasts, cells usually linked to tissue repair, also help regenerate various organs and their ability decreases with age. Turning adult fibroblasts back to a younger state could be a new treatment approach.

Finasteride improves heart function and repairs damage after heart attack in mice.

Fat tissue stem cells show promise for repairing different body tissues and are being tested in clinical trials.

Obesity leads to physical, metabolic, reproductive issues, higher healthcare costs, and mental health problems.

Bone Morphogenetic Proteins (BMPs) help control skin health, hair growth, and color, and could potentially be used to treat skin and hair disorders.

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

The Wnt/β-catenin pathway is important for tissue development and has potential in regenerative medicine, but requires more research for therapeutic use.

Stem cells can rejuvenate skin, restore hair, and aid in wound healing.

Skin stem cells are crucial for maintaining and repairing skin, with potential for treating skin disorders and improving wound healing.

Fibroblast Growth Factor-9 (FGF-9) can help improve heart function in diabetic mice after a heart attack by reducing inflammation and harmful changes to the heart's structure.

Regenerative pharmacology, which combines drugs with regenerative medicine, shows promise for repairing damaged body parts and needs more interdisciplinary research.

Stem cell therapies show promise for treating various diseases but face challenges in clinical use and require better monitoring techniques.

Fibroblast Growth Factor-9 helps repair heart damage after a heart attack by creating new blood vessels, especially in diabetics.

The review concludes that innovations in regenerative medicine, tissue engineering, and developmental biology are essential for effective tissue repair and organ transplants.

Vitamin D and estrogen may help protect heart and kidney health, and maintaining sufficient vitamin D levels could be especially beneficial for African Americans, postmenopausal women, and people with chronic kidney disease.

Jumonji genes are important for development and their mutations can cause abnormalities, especially in the heart and brain.

Pharmacists should interpret lab data and perform physical exams to improve patient care.

Stem cell-derived conditioned medium shows promise for treating various medical conditions but requires standardized production and further validation.

Apigenin, found in plants and vegetables, has many health benefits, including anti-inflammatory, antioxidant, and anticancer effects.

Sox6 is important in heart and kidney health, affecting diseases like diabetes, heart disease, and high blood pressure.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Small molecule drugs show promise for advancing regenerative medicine but still face development challenges.

New drugs for heart disease may be developed from molecules secreted by stem cells.