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GlossaryMale Unpatterned Hair Loss (MUHH)

diffuse thinning of hair across the entire male scalp

Male Unpatterned Hair Loss (MUHH) refers to a type of hair loss in men that does not follow the typical patterns seen in male pattern baldness, such as receding hairlines or balding at the crown. Instead, it involves a more diffuse thinning of hair across the entire scalp. This condition can be more challenging to diagnose and treat because it doesn't exhibit the characteristic patterns of androgenetic alopecia.

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A Newly Identified Missense Mutation of the HR Gene Is Associated with a Novel, Unusual Phenotype of Marie Unna Hereditary Hypotrichosis 1 Including Limb Deformities

research A Newly Identified Missense Mutation of the HR Gene Is Associated with a Novel, Unusual Phenotype of Marie Unna Hereditary Hypotrichosis 1 Including Limb Deformities

6 citations, May 2012 in “Archives of Dermatological Research”

A new mutation in the HR gene is linked to a rare form of hair loss with limb deformities.

research Hair Disorders

November 2019 in “Harper's Textbook of Pediatric Dermatology”

Understanding normal hair growth and loss in children is key to diagnosing and treating hair disorders.

research Hairless And The Polyamine Putrescine Form A Negative Regulatory Loop In The Epidermis

10 citations, August 2013 in “Experimental Dermatology”

Hairless protein and putrescine regulate each other, affecting hair growth and skin balance.

research The Stem Cell Quiescence and Niche Signaling Is Disturbed in the Hair Follicle of the Hairpoor Mouse, an MUHH Model Mouse

October 2021 in “Research Square (Research Square)”

Hair follicle stem cells in hairpoor mice are disrupted, causing hair loss.

research The Stem Cell Quiescence and Niche Signaling Is Disturbed in the Hair Follicle of the Hairpoor Mouse, an MUHH Model Mouse

2 citations, May 2022 in “Stem cell research & therapy”

Disrupted stem cell signals in hairpoor mice cause hair loss.

Loss-Of-Function Mutations of an Inhibitory Upstream ORF in the Human Hairless Transcript Cause Marie Unna Hereditary Hypotrichosis

research Loss-Of-Function Mutations of an Inhibitory Upstream ORF in the Human Hairless Transcript Cause Marie Unna Hereditary Hypotrichosis

181 citations, January 2009 in “Nature Genetics”

Certain mutations in a hair growth-related gene cause a type of genetic hair loss.

research A Novel Mutation in Hr Causes Abnormal Hair Follicle Morphogenesis in Hairpoor Mouse, an Animal Model for Marie Unna Hereditary Hypotrichosis

21 citations, June 2009 in “Mammalian genome”

A new mutation in the Hr gene causes hair loss in mice, similar to a human hair disorder.

research Marie Unna Hereditary Hypotrichosis: Identification of a U2HR Mutation in the Family from the Original 1925 Report

14 citations, April 2011 in “Journal of the American Academy of Dermatology”

Researchers found a gene mutation responsible for a rare hair loss condition.

research Marie Unna Hereditary Hypotrichosis Caused by a Novel Mutation in the Human Hairless Transcript

14 citations, July 2010 in “Experimental Dermatology”

A new mutation in the HR gene causes hair loss in a specific family.

research Marie Unna Hereditary Hypotrichosis: A Turkish Family with Loss of Eyebrows and a U2HR Mutation

11 citations, September 2010 in “American Journal of Medical Genetics - Part A”

A Turkish family with sparse hair and eyebrow loss has a mutation in the U2HR gene linked to Marie Unna hereditary hypotrichosis.

research Identification of a Novel Heterozygous Mutation in the First Japanese Case of Marie Unna Hereditary Hypotrichosis

6 citations, January 2013 in “The Journal of Dermatology”

Researchers found a new genetic mutation causing a rare hair loss condition in the first Japanese child studied.

research Marie-Unna Hereditary Hypotrichosis

4 citations, January 2014 in “International Journal of Trichology”

A 12-year-old boy with a rare genetic condition has progressive hair loss with no effective treatment.

research Poly(rC) Binding Protein 2 Acts as a Negative Regulator of IRES-Mediated Translation of Hr mRNA

3 citations, February 2018 in “Experimental and Molecular Medicine/Experimental and molecular medicine”

A protein called PCBP2 controls the production of a hair growth protein by interacting with its genetic message and is linked to hair loss when this control is disrupted.

research Two Females With Hair Loss

July 2019 in “Journal der Deutschen Dermatologischen Gesellschaft”

A mother and daughter have a rare genetic hair loss disorder with no effective treatment.

research Clinical Course of the First Japanese Family with Marie Unna Hereditary Hypotrichosis: A Follow-Up Report

May 2018 in “European Journal of Dermatology”

The first Japanese family with Marie Unna hereditary hypotrichosis showed hair condition improvement in a child and highlighted the risk of misdiagnosis.

research Thyroidism Effect on Alopecia Patients in Pakistan

November 2021 in “International Journal of Immunology and Microbiology”

Thyroid hormone imbalances can cause hair loss in alopecia patients.

research Odd-Looking Hair and Progressive Alopecia in Mother and Son

May 2014 in “JAMA Dermatology”

Mother and son diagnosed with a rare genetic hair loss condition with no effective treatment.

research A Case of Red Lunulae After Hematopoietic Stem Cell Transplantation

May 2018 in “European Journal of Dermatology”

Adjusting the medication tacrolimus resolved a boy's red nail beds after a stem cell transplant.

research Unveiling the Roots of Monogenic Genodermatoses: Genotrichoses as a Paradigm

26 citations, December 2011 in “Journal of Investigative Dermatology”

New gene identification techniques have improved the understanding and classification of inherited hair disorders.

research Marie-Unna Hereditary Hypotrichosis: Case Report and Review of the Literature

November 2011 in “Pediatric dermatology”

Marie-Unna Hereditary Hypotrichosis is a rare genetic condition causing sparse hair growth, requiring specific recognition for proper care.

research An Open, Randomized, Comparative Study of Oral Finasteride and 5% Topical Minoxidil in Male Androgenetic Alopecia

71 citations, January 2004 in “Dermatology”

Oral finasteride works better than topical minoxidil for hair growth, both are safe.

research Cutaneous Transcriptome Analysis in NIH Hairless Mice

7 citations, August 2017 in “PloS one”

Key genes linked to hair growth and cancer were identified in hairless mice.

research Identification of a Recurrent Nonsense Mutation in HR Gene Responsible for Atrichia with Papular Lesions in Two Kashmiri Families

3 citations, February 2020 in “The journal of gene medicine”

A mutation in the HR gene causes a rare form of irreversible hair loss in two Kashmiri families. Whole exome sequencing is effective for finding such mutations.

research Development of Squamous Cell Carcinoma from Erythroplasia of Queyrat Following Photodynamic Therapy

3 citations, May 2018 in “European Journal of Dermatology”

Photodynamic therapy may not work for erythroplasia of Queyrat and could lead to invasive squamous cell carcinoma.

research Autosomal Recessive Hypotrichosis Simplex With Woolly Hair: A Report of a New Family

1 citations, August 2011 in “Dermatology Reports”

Two siblings were found to have a genetic condition causing progressive hair loss and woolly hair, which may often be misdiagnosed.

research The Role of Histone Demethylases in Disease

1 citations, January 2011 in “Springer eBooks”

Histone demethylases play a key role in the development of many diseases and may be targets for treatment.

research Index

November 2019 in “Harper's Textbook of Pediatric Dermatology”

The document is a detailed medical reference on skin and genetic disorders.

research An Immune Regulatory CCT Repeat Containing Oligodeoxynucleotide Capable of Causing Hair Loss in Male Mice

January 2016 in “Human & Experimental Toxicology”

A specific DNA sequence caused hair loss in male mice by activating immune cells and increasing a certain immune signal.

research Wnt/β-Catenin Signaling: Function, Biological Mechanisms, and Therapeutic Opportunities

318 citations, January 2022 in “Signal Transduction and Targeted Therapy”

The Wnt/β-catenin pathway is important for body functions and diseases, and targeting it may treat conditions like cancer, but with safety challenges.

research Molecular Genetics of the PI3K-AKT-mTOR Pathway in Genodermatoses: Diagnostic Implications and Treatment Opportunities

36 citations, January 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

The document concludes that understanding genetic mutations in the PI3K-AKT-mTOR pathway can lead to better diagnosis and treatment for certain genetic skin disorders.