Two Females With Hair Loss
July 2019
in “
Journal der Deutschen Dermatologischen Gesellschaft
”
Studysummary This source reports findings from a case study detailing hair loss in two female patients, published in the JDDG: Journal der Deutschen Dermatologischen Gesellschaft, emphasizing that specific diagnostic outcomes or treatment results are not included in the summary. Our plain-language summary of this paper — not a Tressless recommendation.
Two females, a 48-year-old mother and her 16-year-old daughter, presented with hair loss, characterized by sparse or absent eyebrows and eyelashes, and progressive scalp hair loss starting at puberty. Both were diagnosed with Marie Unna hereditary hypotrichosis (MUHH), a rare autosomal dominant hair disorder caused by a genetic defect in the U2HR gene. The condition leads to coarse, wiry hair that becomes sparse over time, particularly in the axillary and pubic regions. Molecular genetic testing confirmed a previously undescribed mutation in the U2HR gene. There is currently no effective treatment for MUHH, and affected individuals often resort to wearing wigs.
