Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study demonstrates that a 3D-printed agarose microwell platform supports the growth of size-uniform, viable NSCLC cancer spheroids, and can effectively evaluate drug responses using limited tumor material from biopsies, particularly with EGFR tyrosine kinase inhibitors gefitinib and osimertinib.

This study developed in vitro methods to regenerate hair follicles and erector muscles by mimicking their native structures and mechanical conditions, reconstructing hair follicle-like structures and forming muscle-like tissues.

This study developed a microdroplet technology to produce cell microspheres that successfully induced hair follicle regeneration in a mouse model, suggesting potential improvements in hair loss treatments.

In this study, researchers used advanced techniques to map the early embryonic development of mouse skin, identifying diverse cell populations and uncovering complex interactions essential for skin structure, signaling, and function.

This study reports that myoepithelial cells in submucosal glands can act as reserve stem cells, regenerating surface airway epithelium after severe injury through a mechanism involving Sox9 and Wnt signaling.

This study found that human dermal papilla cells are surrounded by a basement membrane-like extracellular matrix, which maintains their aggregated structure without strong cell‒cell contacts.

This study found that transplanting cell aggregates from mouse skin and lung mesenchymal cells can regenerate hair follicles in immunodeficient mice with skin wounds.

This study suggests that MultiDomain Peptide hydrogels may support wound healing in diabetic mice by accelerating closure and promoting tissue regeneration, though they did not inhibit bacterial growth in infected wounds as expected.

This study introduced a high-viscosity epoxy photoresist to enhance the fabrication of complex microstructures with monolithic integration and mechanical stability, enabling advancements in two-photon 3D printing for creating functional micro-mechanical devices.

This study developed microfluidic-assisted GelMA-MSC/HAD-EPC microspheres that efficiently generated hair follicles in nude mice, suggesting a promising strategy for advancing hair-regenerative medicine.

This study introduces a method for long-term expansion of adult mouse epidermal stem cells in vitro using an organoid culture system that maintains the basal-apical organization.

This study found that mesenchymal cell processes from the dermal papilla contact epithelial hair matrix cells through gaps in the basal lamina during hair matrix cell differentiation in mouse vibrissa follicles.

This review found that microinfusion of medications using tattoo devices (MMP®) shows potential as a minimally invasive method for treating ailments like alopecia and basal cell carcinoma, offering notable improvements with minimal side effects due to localized drug delivery.

In this study, mixing mouse epithelial and dermal cells was the most successful method for reconstituting hair follicles in mice, with the hair patch assay providing the quickest results.

This review discusses various types of microneedles and their potential to expand the range of drugs delivered via the skin, but reports no new clinical results.

This study found that inserting isolated hair follicle units into engineered dermis promoted differentiation and maturation of tissue-engineered skin, maintaining hair follicle morphology and generating skin appendages like sebaceous glands.

This review discusses the role of epithelial mesenchymal transition (EMT) in wound healing and tissue repair, highlighting its potential contributions to progenitor cell pools, but reports no new clinical findings.

In this study, researchers found that electrospun membranes with aligned surface topography advanced the immune response towards an adaptive stage and highlighted the role of T cells in hair follicle regeneration in mice, showcasing the intricate interactions between immune and skin cells.

Understanding tissue self-organization can improve treatments for diseases and advance regenerative medicine.

This study observed that using ex vivo gene therapy to modify skin cells in a pre-graft model improved dermal-epidermal junction adhesion strength and maintained collagen production over time, suggesting a potential treatment approach for recessive dystrophic epidermolysis bullosa skin wounds.

This study suggests that Merkel cell polyomavirus T antigen-positive cells resembling Merkel cell carcinoma may originate from epithelial cells in human hair follicles, potentially informing future transgenic mouse models for this cancer.

This chapter reports an organ culture method that permits mouse embryonic skin tissues to develop similarly to in vivo conditions, revealing that epidermal growth factor inhibits hair follicle formation.

This study demonstrates that human epidermal stem cells can adapt to environmental temperature changes through mTOR signaling, and prolonged inhibition of mTORC1 supports stem cell maintenance, which may be vital for regenerative medicine.

The researchers reported that in hairless mice, epidermal cell division orientations and epidermal thickness varied by body site, with dorsal and ear epidermis primarily dividing parallel to the basement membrane, unlike hind paw and tail epidermis.

In this study, researchers developed a novel bio-patch from decellularized freeze-dried tumor tissues and hair melanin nanoparticles, which demonstrated enhanced wound healing in vivo by reducing oxidative stress, suppressing inflammation, and promoting angiogenesis.

This study developed molecular signatures for dermal papilla cells and their niche, uncovering novel signaling regulators and genes linked to hair disorders, which may inform future hair development research.

In this study, researchers reported telocytes in the dermis of silky fowl embryos at different developmental stages, highlighting their immunophenotypes and interactions with other cells.