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416 citations,
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252 citations,
January 2008 in “Trends in Endocrinology and Metabolism” Melatonin in the skin helps protect against damage from stress and UV rays, and could be used to treat certain skin conditions.
245 citations,
January 2018 in “Bone Research” TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.
222 citations,
October 2014 in “Annual Review of Pharmacology and Toxicology” Eph receptors and ephrins may be promising targets for treating diseases, but more understanding is needed for effective and safe therapies.
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January 2015 in “International journal of trichology” Dermatologists need to understand hair products to treat hair and scalp issues better.
191 citations,
November 1959 in “Annals of the New York Academy of Sciences” Hair and wool have complex microscopic structures with microfibrils and varying cystine content.
159 citations,
March 2014 in “Journal of The American Academy of Dermatology” Some skin medications are safe during pregnancy and breastfeeding, but others can harm the baby and should be avoided.
141 citations,
November 2005 in “International journal of pharmaceutics” Hair follicles may soon be used more for targeted and systemic drug delivery.
128 citations,
January 1996 in “Journal of analytical toxicology.” Hair analysis can detect cocaine use but doesn't accurately show the amount or timing of use.
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May 2003 in “Toxicological Sciences” Exposure to finasteride in the womb caused lasting reproductive issues in male rats.
116 citations,
August 2010 in “Nature” Scientists turned rat thymus cells into stem cells that can help repair skin and hair.
107 citations,
August 2012 in “Seminars in Cell & Developmental Biology” The document concludes that understanding the sebaceous gland's development and function is key to addressing related skin diseases and aging effects.
84 citations,
February 2013 in “Clinica chimica acta” Hair mineral analysis might help diagnose diseases early, but standard methods are needed.
82 citations,
October 2019 in “Frontiers in Immunology” Changes to the Foxp3 protein affect how well regulatory T cells can control the immune system, which could help treat immune diseases and cancer.
75 citations,
October 2002 in “Journal of Dermatological Science” Sophora flavescens extract may help hair grow by affecting growth factors and blocking a hair-related enzyme.
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December 2009 in “Organic and Biomolecular Chemistry” Mercuric triflate is an effective catalyst for various organic reactions, working well at room temperature with high yields.
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October 1998 in “Baillière's clinical endocrinology and metabolism” Long-term testosterone therapy can cause hormone suppression, affect prostate and heart health, and alter physical characteristics, but does not increase prostate cancer risk and needs more research for full risk assessment.
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December 2013 in “Aaps Journal” Squarticles effectively deliver hair growth drugs to follicles and dermal papilla cells.
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December 2017 in “Journal of The European Academy of Dermatology and Venereology” Microneedling can help stimulate hair growth, especially when used with other treatments, but it's not better than existing therapies.
57 citations,
January 1980 in “Journal of Cardiovascular Pharmacology” Minoxidil treats high blood pressure and side effects can be managed.
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November 2018 in “American journal of human genetics” Mutations in the LSS gene cause a rare type of hereditary hair loss.
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August 2019 in “American journal of human genetics” FOXN1 gene variants cause low T cells and immune issues from birth.
50 citations,
September 1975 in “American Heart Journal” Minoxidil effectively controls blood pressure in severe cases, but may cause fluid retention and edema.
49 citations,
August 2016 in “Aesthetic Surgery Journal” Micro-needling effectively improves wrinkles, scars, and hair growth, but proper technique and safety are important.
49 citations,
February 2009 in “Maturitas” Short-term testosterone therapy in women seems safe with few mild side effects, but long-term effects need more research.
49 citations,
July 2004 in “Anesthesiology” The document concludes that more research is needed to understand how to treat muscle pain with drugs.
48 citations,
September 2017 in “Frontiers in Bioscience” Nanoparticles show promise for better wound healing, but more research is needed to ensure safety and effectiveness.
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March 2019 in “Journal of immunology research” Valproic Acid could potentially be used to treat immune-related conditions due to its ability to modify immune cell functions.