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Pig skin is a good substitute for human skin to measure drug absorption, but differences in skin structure and enzymes across species must be considered.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

Lower SHBG levels may increase the risk of PCOS.

New hormonal contraceptives are safer, have fewer side effects, and offer health benefits for women.

PCOS is a common hormonal disorder in women, marked by symptoms like hair growth and menstrual issues, and requires personalized treatment.

PCOS starts in adolescence with hormonal issues, leading to adult health problems, and early treatment is crucial.

The document concludes that early recognition and treatment of PCOS in adolescents is crucial for managing symptoms and long-term health risks.

Blocking a specific enzyme might help treat obesity and diabetes, but more research is needed to ensure it's safe.

Polycystic Ovary Syndrome is linked to higher risk of hypertension and heart disease.

People with alopecia are at higher risk for heart disease and have more heart-related risk factors.

The document suggests creating a validated score to diagnose Cushing's Syndrome and considers plasma steroid profiling as a simpler diagnostic method.

Women with PCOS are more likely to have insulin resistance and obesity, especially those with the most severe type I PCOS.

The document concludes that computational methods using networks and various data can improve the process of finding new uses for existing drugs.

Women with PCOS have a higher risk of diabetes, heart problems, certain cancers, and mental health issues, but early treatment can help manage these risks.

Menstrual disorders are common in adolescents and can be influenced by weight, activity, and health issues, requiring careful evaluation and more research for effective treatment.

Testosterone therapy may slightly improve sexual function in postmenopausal women, but its long-term safety is unknown.

Girls with PCOS during adolescence have a higher risk of developing type 2 diabetes, and early treatment can help manage this risk.

Most skin changes during pregnancy are harmless and temporary, but some can risk the fetus and need careful treatment.

Acitretin is effective for severe psoriasis and can be used long-term due to no immunosuppression, but must be carefully monitored for side effects and is not for pregnant women.

Early diagnosis and treatment are key to managing health risks in teens with PCOS.

Chromium supplements don't improve insulin, hormone levels, or cholesterol in women with PCOS but raise testosterone levels.

Non-immune factors play a significant role in alopecia areata.

The document concludes that more research is needed to fully understand the causes of PCOS.

Plant-based remedies may treat hair loss by reducing inflammation and improving insulin resistance.

Vitamin D and estrogen may help protect heart and kidney health, and maintaining sufficient vitamin D levels could be especially beneficial for African Americans, postmenopausal women, and people with chronic kidney disease.

Testosterone therapy seems safe for short-term use in postmenopausal women with low sexual desire, but more research on long-term effects is needed.

Some men with early hair loss may have a male version of PCOS, affecting hormones and increasing health risks.

Testosterone treatment can improve sexual function and bone density in women but may have adverse effects and requires more research on safety and guidelines.

Blood removal and birth control pills both helped with hormone levels in women with PCOS, but birth control was better for regular periods and blood removal had fewer side effects.

Testosterone therapy for transmasculine individuals is generally safe with medical supervision, improves mental health, and has mixed effects on physical health.