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Protocatechuic acid can reduce melanin production and boost antioxidant activity in hair follicles.

Melanocytes are destroyed by factors needed for melanin production, causing vitiligo and gray hair.

As people age, their hair follicles produce less pigment, leading to gray and white hair, due to factors like reduced enzyme activity and damage to melanocyte DNA.

Notch/RBP-J signaling is crucial for proper placement and timing of melanocyte development in hair follicles.

Hair greying is caused by oxidative stress damaging hair follicles and melanocytes.

Hair graying may be caused by stem cell depletion from stress or melanocyte damage.

FFA patients have fewer melanocytes and thinner skin compared to others.

White hair follicles in vitiligo have fewer and less functional melanocytes.

Beige and leaden pigment genes act within melanocytes, affecting pigment patterns.

New treatments for vitiligo may focus on protecting melanocyte stem cells from stress and targeting specific pathways involved in the condition.

Langerhans cells and melanocytes migrate to the skin and hair follicles during early human development.

Segmental vitiligo affects hair follicle melanocytes, causing small, uniform depigmented spots.

The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.

The skin's layers protect, sense, and regulate the body's internal balance, but can be prone to cancer.

Melatonin is important for skin health and protection, and can be made by the skin or applied to it.

Androgens can both increase and decrease hair growth in different parts of the body.

Estrogens can improve skin aging but carry risks; more research is needed on safer treatments.

Stem cells in the hair follicle are regulated by their surrounding environment, which is important for hair growth.

We need more research on human hair follicle pigmentation, not just mouse models.

Human hair follicle stem cells can be isolated using specific markers for potential therapeutic use.

Mouse skin can produce and process serotonin, with variations depending on hair cycle, body location, and mouse strain.

The conclusion is that tissue structure is key for stem cell communication and maintaining healthy tissues.

Certain genes control the color of human hair by affecting pigment production.

Minoxidil and Finasteride are effective for male baldness; more research is needed for hair aging treatments.

Hair color loss can indicate the effectiveness of a drug targeting the KIT protein in mice and humans.

Advanced human skin models improve drug development and could replace animal testing.

Hair follicle stem cells are a promising source for tissue repair and treating skin or hair diseases.

Vitiligo causes white skin patches and is linked to autoimmune issues.

Surgical methods like suction blister grafting and split-thickness skin grafting are highly successful for vitiligo repigmentation, but choosing the right patients is crucial for success.

MicroRNAs are crucial for controlling skin development and healing by regulating genes.