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Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

The conclusion is that certain cell interactions and signals are crucial for hair growth and regeneration.

Certain proteins, Lgr5 and Lgr6, are important markers of adult stem cells and are involved in tissue repair and cancer development.

Chemicals and body size might change when puberty starts and progresses, but more research is needed to confirm this.

Epithelial-mesenchymal interactions control hair growth cycles through specific molecular signals.

The document concludes that mouse models are helpful but have limitations for skin wound healing research, and suggests using larger animals and genetically modified mice for better human application.

Growing human skin cells in a 3D environment can stimulate new hair growth.

A protein from certain immune cells is key for new hair growth after skin injury in mice.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Stem cells help heal skin wounds by moving and changing roles, working with other cells, and needing more research on their activation and behavior.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

Bone Morphogenetic Proteins (BMPs) help control skin health, hair growth, and color, and could potentially be used to treat skin and hair disorders.

Flutamide is more effective and has fewer side effects than spironolactone for treating hirsutism.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Stem cell self-renewal is complex and needs more research for full understanding.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

Sonic hedgehog signaling is crucial for hair growth and maintaining hair follicle identity.

Estrogen replacement can improve skin health in menopausal women but doesn't reverse sun damage or prevent hair loss.

Different types of stem cells with unique roles exist in blood, skin, and intestines, and this variety is important for tissue repair.

Estrogen loss during menopause worsens skin health, but hormone replacement therapy may improve it, though more research is needed.

Different types of stem cells and their environments are key to skin repair and maintenance.

TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.

Flutamide effectively reduced excessive hair growth and improved related symptoms in hirsutism patients without significant side effects.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

The document concludes that while significant progress has been made in understanding skin biology and stem cells, more research is needed to fully understand their interactions with their environment.

Flutamide rarely causes liver toxicity in prostate cancer patients.

Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.