October 2013 in “The American Journal of Gastroenterology” This case study reports a diagnosis of the rare Cronkhite-Canada syndrome in a 60-year-old man, who showed symptom improvement following treatment with prednisone and azathioprine.
47 citations
,
July 1967 in “Science” This study observed morphological changes in scalp hair follicles of humans deprived of protein for 15 days, which suggests potential use in diagnosing protein-calorie malnutrition.
82 citations
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April 1981 in “Clinical endocrinology” This study describes a case of vitamin D resistant rickets in a young girl due to end organ unresponsiveness, highlighting a possible new subtype of the disorder with distinct clinical features.
15 citations
,
March 1996 in “PubMed” This study found that 82.3% of girls with anorexia nervosa had pili torti, an acquired hair defect, suggesting a potential link to excess vitamin A intake.
January 2000 in “The Journal of Trace Elements in Experimental Medicine” In this case report, an 11-year-old girl with acrodermatitis enteropathica experienced a complete resolution of symptoms following oral zinc therapy, highlighting its effectiveness in managing this condition.
1 citations
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May 2023 in “Cutis” In this source, it is highlighted that dermatologists can identify and manage eating disorders early, potentially improving outcomes and reducing irreversible damage from malnutrition, though specific results are not reported.
April 2026 in “Zenodo (CERN European Organization for Nuclear Research)” In this case study, a daily morning Detox Drink combined with Malasana improved bowel frequency, stool consistency, and other constipation-related symptoms in a 37-year-old woman with chronic Malabaddha.
12 citations
,
January 1987 in “Ophthalmic Paediatrics and Genetics” This report describes a patient with biotinidase deficiency presenting bilateral optic atrophy, and confirms autosomal recessive inheritance through enzyme dosage analysis in the patient and family members.
January 2020 in “Turkish Journal of Dermatology” This case report describes a 9-month-old boy with zinc deficiency-related symptoms, including hair loss and diarrhea, ultimately diagnosed as acrodermatitis enteropathica and improved with zinc therapy.
1 citations
,
January 2020 in “Saudi Surgical Journal” This review found that bariatric surgery may lead to zinc deficiency and alopecia, more commonly affecting females, suggesting further research is needed to evaluate the benefit of micronutrient supplementation.
1 citations
,
November 2011 in “Turkish Journal of Dermatology” In this case report, a 6-year-old male with biotinidase deficiency experienced marked improvement in dermatological symptoms, including alopecia and periorificial lesions, following biotin treatment.
11 citations
,
December 2010 in “Archives of Dermatology” This abstract provides no research results, focusing instead on navigation and subscription details for JAMA Dermatology content access.
4 citations
,
April 2018 in “The journal of pediatrics/The Journal of pediatrics” This case report discusses a 6-year-old girl with loose anagen hair syndrome, characterized by painlessly shedding hair, and notes no evidence of benefit from biotin supplementation.
72 citations
,
October 1992 in “Archives of Dermatology” This study describes five patients whose cystic fibrosis was initially indicated by a rash associated with protein-energy malnutrition, highlighting the importance of early symptom recognition for timely diagnosis and treatment.
April 2015 in “Our Dermatology Online” This report presents a case of acrodermatitis enteropathica in a 22-year-old female, highlighting the absence of underlying comorbid conditions.
2 citations
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February 1945 in “Archives of Dermatology and Syphilology” This case report describes a woman with an unusual presentation of tinea capitis, noting diagnostic challenges as initial examinations found no mycelium or spores.
January 2016 in “ACG Case Reports Journal” This case report describes a 4-year-old girl with Rapunzel syndrome, presenting with severe anemia and a contained perforation, who underwent successful surgical removal of a large gastric trichobezoar.
August 2021 in “Journal of medical science and clinical research” This case report describes an 11-month-old infant with Biotinidase deficiency who exhibited multifocal seizures, neuroregression, alopecia, and skin issues, highlighting prompt diagnosis and the dramatic clinical response to biotin treatment.
1 citations
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February 2023 in “Digestive Diseases and Sciences” This study observed that 46% of gastroparesis patients reported hair loss, which was associated with more severe gastroparesis symptoms and weight loss, and multivitamin treatment improved hair loss in 40% of these patients.
March 2023 in “Mağallaẗ wāsit li-l-ʿulūm wa-al-ṭibb” This case report details a family in Iraq with biotin deficiency, highlighting improved outcomes in surviving children following diagnosis and lifelong biotin supplementation.
363 citations
,
May 2006 in “Current Opinion in Psychiatry” This review highlights that medical complications, notably in anorexia nervosa, are common and often serious in patients with eating disorders, affecting multiple organ systems.
1 citations
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June 2022 in “JCRPE” This study reports that metreleptin treatment in a boy with congenital generalized lipodystrophy significantly improved metabolic complications and overall health outcomes during the first year of therapy.
September 2010 in “Middle East Journal of Digestive Diseases” This case report highlights that treating ulcerative colitis with azathioprine and mesalamine led to hair regrowth in a middle-aged man with recent onset alopecia universalis, suggesting skin manifestations can be an extraintestinal indication of the disease.
17 citations
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April 2004 in “Acta Clinica Belgica” This study found that ultraviolet light-enhanced visualization can detect subtle skin changes linked to carotene and vitamin A deficiency, which improved with dietary correction in deficient individuals.
This study identified rare nucleotide substitutions in the SLC39A4 gene in children with acrodermatitis enteropathica, suggesting a genetic component to the disease's etiology.
64 citations
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August 2014 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology” This study found that biallelic mutations in the TTC7A gene affect lymphocyte and gut epithelial cell function, thereby contributing to the development of inflammatory bowel disease in patients.
29 citations
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January 1963 in “PubMed”
16 citations
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July 2012 in “The New England Journal of Medicine” This case report describes a 27-year-old man hospitalized with fatigue, myalgias, weakness, profound weight loss, and abnormal liver function, leading to a diagnosis after chest imaging revealed pneumomediastinum.
December 2019 in “The American Journal of Gastroenterology” In this study, three cases of Cronkhite-Canada syndrome revealed small bowel mucosal lesions, but these findings did not correlate with clinical symptoms or steroid treatment outcomes.
5 citations
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February 2025 in “Cell Reports” In this study, inducible whole-body Acly-knockout mice revealed that ACLY is essential for skin homeostasis, as its deficiency led to increased sebum production and skin abnormalities, indicating a vital role for cytosolic acetyl-CoA synthesis in preserving skin barrier integrity and systemic lipid regulation.