Multiple Myeloma-Associated Amyloidosis Presenting With Acrolocalized Acquired Cutis Laxa
December 2010
in “
Archives of Dermatology
”
TLDR A man with rare skin changes on his fingers was diagnosed with multiple myeloma-linked amyloidosis.
The document reports a case of a 63-year-old man who presented with acrolocalized acquired cutis laxa (CL), a rare form of localized CL that can indicate underlying multiple myeloma. The patient had asymptomatic skin lesions on his fingers, with skin changes more pronounced on the fingertips. Biopsy and immunohistochemical analysis confirmed the presence of amyloid deposits and a reduction in dermal elastic fibers, leading to a diagnosis of multiple myeloma-associated amyloidosis and acral localized acquired CL. The study emphasizes the importance of recognizing cutaneous laxity and temporary dimpling of the skin after pressure as potential clinical signs of monoclonal gammopathy. The histopathologic findings, including amyloid deposits with monotypic expression of light chains and diminished dermal elastic fibers, were key to diagnosing the associated multiple myeloma.
