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Human skin can make serotonin and melatonin, which help protect and maintain it.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Calreticulin has roles in healing, immune response, and disease beyond its known functions in the endoplasmic reticulum.

The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

Super-enhancers controlled by pioneer factors like SOX9 are crucial for stem cell adaptability and identity.

Fat tissue-derived cells show promise for repairing body tissues, but more research and regulation are needed for safe use.

The skin has a complex immune system that is essential for protection and healing, requiring more research for better wound treatment.

The document concludes that the understanding of scar formation is incomplete and current prevention and treatment for hypertrophic scars and keloids are not fully effective.

Polysaccharides have many health benefits and are used in drugs, but isolating and purifying them is complex and requires careful methods.

The research found that different types of fibroblasts are involved in wound healing and that some blood cells can turn into fat cells during this process.

Air pollution worsens skin diseases and aging by causing inflammation and oxidative stress.

Alopecia areata, a common autoimmune hair loss condition, often runs in families.

Adult stem cells from rat whisker follicles can regenerate hair follicles and sebaceous glands.

Apple polyphenol, especially oligomeric procyanidins, can reduce fat absorption and lower blood fat levels.

Treatments that reduce oxidative stress and fix mitochondrial problems may help heal chronic wounds.

Removing part of the vitamin D receptor stops vitamin D from working properly.

Some drugs can cause rare but potentially deadly skin reactions, and early treatment and avoiding the drug again are key.

The research shows that a gene called Wnt3 affects hair growth and structure, causing short hair and balding when overactive.

Niosomes improve minoxidil skin delivery for hair loss treatment.

The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

Polymeric nanoparticles show promise for treating skin diseases.

Medium-sized particles penetrate hair follicles better than smaller or larger ones, which could improve delivery of skin treatments.

Niosomes are a promising, stable, and cost-effective drug delivery system with potential for improved targeting and safety.

The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.

Stem cell offspring help control their parent stem cells, affecting tissue health, healing, and cancer.

Teriflunomide helps reduce multiple sclerosis symptoms and is safe for most patients.

The immune system plays a key role in tissue repair, affecting both healing quality and regenerative ability.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Chitin and chitosan are useful in cosmetics for oral care, haircare, and skincare, including UV protection and strength improvement.