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Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Calreticulin has roles in healing, immune response, and disease beyond its known functions in the endoplasmic reticulum.

Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

Skin cells produce and activate vitamin D, which regulates skin functions and supports hair growth.

Protoporphyrin IX is useful in cancer treatment but can cause health problems if not properly regulated.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

Hormones, especially androgens, play a big role in acne, but most acne sufferers don't have a hormone disorder. Hormonal treatments, including birth control pills, can be very effective for women whose acne doesn't improve with regular treatments.

The document concludes that certain genetic mutations and dietary factors are involved in acne development, and treatments like isotretinoin and diet changes can help manage it.

The conclusion is that managing androgen excess requires long-term treatment, including hormonal contraceptives and androgen blockers, with follow-up after six months.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Blocking a specific enzyme might help treat obesity and diabetes, but more research is needed to ensure it's safe.

Certain fungi and bacteria help orchid seeds germinate and plants grow better.

Polycystic Ovary Syndrome is linked to higher risk of hypertension and heart disease.

Glutamine metabolism affects hair stem cell maintenance and their ability to change back to stem cells.

The protein StAR is found in 17 different organs and can affect hair loss and brain functions, but its full role is not yet fully understood.

Plant steroid hormones show growth, health, and medicinal benefits in various organisms, including potential for treating diseases.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Adrenal disorders can cause lasting brain and behavior issues in children.

The study developed a tool to predict how gut microbes process foods and drugs, showing that similar compounds often share metabolic pathways and effects.

Graphene oxide and indole-3-acetic acid together inhibit root growth in Brassica napus L. by affecting multiple plant hormone pathways.

The document concludes that inherited epidermolysis bullosa is a challenging genetic condition requiring multidisciplinary care and new treatments.

Melatonin protects skin against UV damage by regulating various cellular processes.

Both immature and mature fat cells are important for hair growth cycles, with immature cells promoting growth and mature cells possibly inhibiting it.

Parkinson's disease is linked to skin disorders and skin cells help in studying the disease.

Safflower has been used in traditional medicine for centuries and shows promise in treating heart, brain, and inflammatory conditions, but more research is needed to ensure its safety.

Genetic research has advanced our understanding of skin diseases, but complex conditions require an integrative approach for deeper insight.

Women's ovarian hormones and adrenal androgens change throughout life, affecting hair loss and health.

Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.