38 citations
,
July 1989 in “Archives of dermatological research” Testosterone causes hair loss in AGA mice, which are good for testing baldness treatments, and both minoxidil and cyproterone acetate can prevent this hair loss.
37 citations
,
October 2014 in “Maturitas” This review discusses the mechanisms and treatment strategies for age-related hair changes, such as androgenetic alopecia and hair graying, and reports no new clinical results.
36 citations
,
October 2014 in “Langmuir” This study concluded that bleach treatment partly transforms the hydrophobic top layer of human hair cuticles into a hydrophilic surface with clustered cysteic acid, visualized at the nano-scale using dynamic Chemical Force Microscopy.
35 citations
,
December 2006 in “Journal of medicinal food” This study found that topical application of Morinda pubescens fruit extract significantly accelerated wound healing and hair regrowth in rats compared to controls, with complete wound contraction and new hair growth observed in treated animals.
34 citations
,
August 2003 in “Clinical and Experimental Dermatology” This study found that hair diameter increases toward the scalp during pregnancy, a novel observation compared to the normal decrease seen in nonpregnant women.
34 citations
,
September 1992 in “Journal of the American Academy of Dermatology” This article provides dermatology residents with essential information on cosmetic use to help manage skin conditions and reactions, without reporting new clinical results.
32 citations
,
May 2018 in “Cell Cycle” This study found that melatonin exposure promoted hair follicle fiber growth in Cashmere goat cultures, potentially influencing pathways related to the microvascular system and extracellular matrix.
32 citations
,
October 1999 in “Journal of women's health and gender-based medicine” This study found that women with androgenetic alopecia report various negative impacts on their lives due to hair thinning, highlighting emotional concerns and dissatisfaction with appearance.
31 citations
,
January 2017 in “Advances in Experimental Medicine and Biology” This review discusses the negative health impacts of testosterone deficiency and the potential adverse effects of 5α-reductase inhibitors, emphasizing the need for patient-physician discussions regarding these treatments.
30 citations
,
July 2019 in “Endocrinology” This review discusses how the HSD3B1(1245C) genotype may impact androgen physiology and the progression of castration-resistant prostate cancer, and does not report new experimental results.
30 citations
,
March 2017 in “ACS biomaterials science & engineering” This review discusses the structure and regenerative potential of hair follicles, highlighting their role in wound healing, stem cell populations, and keratin-based biomaterials, but it reports no new clinical results.
30 citations
,
January 2016 in “Journal of Pharmaceutical and Biomedical Analysis” This study identified trilauric glyceride and decanoylcarnitine as potential biomarkers for diagnosing PCOS in patients with and without insulin resistance, suggesting significant metabolic alterations in these conditions.
29 citations
,
February 2018 in “European Journal of Immunology” In this study, Treg depletion impaired skin wound healing in mice, potentially by altering the cytokine environment and expanding certain T-cell populations, disrupting the normal healing process.
28 citations
,
September 2020 in “Pharmaceutics” This review discusses the potential of three-dimensional printed mesoporous scaffolds for drug delivery applications, particularly for bone cells and tissues, but reports no new clinical results.
28 citations
,
May 1998 in “Skin Research and Technology” This study characterized the stress-strain properties of the human scalp and found that its stiffness increases significantly with load, providing valuable insights for planning scalp surgery procedures.
27 citations
,
October 2001 in “Journal of Medicinal Chemistry” This study identified eight isoflavone derivatives as potential nonsteroidal inhibitors of rat 5α-reductase using a pharmacophore model in virtual screening.
23 citations
,
January 2010 in “Journal of Medical Primatology” This study found that alopecia in captive Rhesus macaques may be linked to chronic hypersensitivity dermatitis with CD4+ cell inflammation, possibly influenced by altered housing and reduced pathogen exposure.
22 citations
,
January 2021 in “Pharmacognosy Journal” This review discusses the traditional uses, phytochemical, and pharmacological studies on Ageratum conyzoides, Tridax procumbens, and Bidens pilosa, emphasizing the need for further clinical research into their medicinal potential, but it does not report new results.
22 citations
,
November 2011 in “Journal of Analytical Toxicology” This review discusses the relevance of human androgen receptor action in sports doping and examines the potential of cell-based biological assays for detecting androgenic anabolic steroid use, without presenting new research findings.
21 citations
,
July 2019 in “Cardiovascular Research” This study found that prenatal exposure to androgens caused long-lasting heart remodeling and left ventricular hypertrophy in female mice offspring, suggesting potential cardiac risks for daughters of mothers with PCOS.
21 citations
,
June 2018 in “Current Opinion in Genetics & Development” This review discusses recent advancements in regenerative medicine, including functional organ regeneration and the creation of mini-organs, and reports no new clinical results.
19 citations
,
December 2019 in “Steroids” This study found that the pharmacological inhibition of 5-α reductases with finasteride and dutasteride can reduce neurosteroid synthesis in glioblastoma-derived cell lines, potentially impacting GBM survival.
19 citations
,
October 2018 in “PLOS ONE” This study found that 5-alpha-reductase inhibitor monotherapy for symptomatic benign prostatic hyperplasia showed some clinical benefit over placebo but was linked to a higher incidence of sexual side effects.
19 citations
,
July 2018 in “ACS biomaterials science & engineering” This study showed that chemical and mechanical treatments significantly alter the nanoscale surface properties of hair, affecting its roughness, mechanical stiffness, adhesion, and surface potential.
18 citations
,
February 2023 in “PLoS ONE” This study developed a triple drug delivery system using nanoparticles loaded with 5-fluorouracil, curcumin, and piperine to target breast tumors, demonstrating notable in vitro cytotoxicity and anti-metastatic potential in 3D tumor spheroids which suggests its promise for further preclinical evaluation.
18 citations
,
January 2020 in “Acta dermato-venereologica” This overview discusses advancements in the understanding of molecular genetics in heritable keratinization disorders, focusing on recent cases of inherited ichthyosis, and reports no new clinical results.
18 citations
,
February 2010 in “Odontology” This report describes Rabson-Mendenhall syndrome cases in two siblings and briefly reviews the literature, highlighting insulin receptor gene mutations as the underlying cause.
18 citations
,
June 1988 in “Culture, medicine and psychiatry” This paper examines how societal constructs of gender influence the treatment of idiopathic hirsutism in women, emphasizing the impact of perceived femininity on psychological stress and commercial depilatory actions.
17 citations
,
April 2020 in “Dermatology and Therapy” In this randomized double-blind study, 160 adults with alopecia areata showed significant improvements in hair loss severity after using a bioactive peptide cosmetic product that mimics platelet-rich plasma, while the placebo group showed no significant change, underlining the treatment's potential effectiveness.
17 citations
,
June 2011 in “The journal of investigative dermatology/Journal of investigative dermatology” This study observed that mice with a Cx43 mutation exhibited slower and asynchronous hair regrowth with severe cuticle weathering, mimicking aspects of hair phenotype in some ODDD patients.