Drug Delivery Applications of Three-Dimensional Printed Mesoporous Scaffolds

The document reviewed the potential of three-dimensional printed (3DP) mesoporous scaffolds in drug delivery, focusing on their high surface area and pore volume which are beneficial for applications in bone cells and tissues. It detailed various 3DP techniques like fused deposition modeling, material jetting, electron beam melting, selective laser sintering, stereolithography, digital light processing, electrospinning, and two-photon polymerization, and their use in creating scaffolds with controlled drug release. The review highlighted the interdisciplinary nature of materials science and nano-microfabrication in advancing pharmaceutics and biopharmaceutics. It also discussed the integration of trace elements into 3DP mesoporous bioactive glass scaffolds to enhance osteogenic activity, the loading of drugs for controlled release, and the potential for personalized drug delivery systems. The document concluded that while some techniques like electron beam melting have not yet been applied to mesoporous devices in drug delivery, others have shown success, and the future of drug delivery will benefit from the development of new biodegradable biopolymers and post-printing processes.