research Identification of the Cell Lineage at the Origin of Basal Cell Carcinoma
Basal cell carcinoma mostly starts from cells in the upper skin layers, not hair follicle stem cells.
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research Recent Advances in the Genetics of Alopecia Areata
New research has found 14 genes linked to the risk of developing alopecia areata, improving understanding and treatment options.
research Genome Array on Differentially Expressed Genes of Skin Tissue in Cashmere Goat at Early Anagen of Cashmere Growth Cycle Using DNA Microarray
Researchers found 24 genes that change significantly and affect cashmere growth in goats; this could help increase cashmere production.
research Chapter 4: Cytomechanics of Hair
Hair's strength and flexibility come from its protein structure and molecular interactions.
research An Integrated Analysis of Cashmere Fineness lncRNAs in Cashmere Goats
lncRNA XLOC_008679 and gene KRT35 affect cashmere fineness in goats.
research Systematic Analysis of Non-coding RNAs Involved in the Angora Rabbit Hair Follicle Cycle by RNA Sequencing
Non-coding RNAs play key roles in the hair growth cycle of Angora rabbits.
research Oral Ruxolitinib Induces Hair Regrowth in Patients with Moderate-to-Severe Alopecia Areata
Ruxolitinib effectively regrows hair in most patients with severe hair loss.
research Human Skin Stem Cells and the Aging Process
Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.
research Hair Follicles, Their Disorders, and Their Opportunities
Hair follicles offer promising targets for delivering drugs to treat hair and skin conditions.
research In Vivo Transcriptional Governance of Hair Follicle Stem Cells by Canonical Wnt Regulators
Wnt signaling controls whether hair follicle stem cells stay inactive or regenerate hair.
research Dermal Niche Signaling and Epidermal Stem Cells
Skin health and repair depend on the signals between skin stem cells and their surrounding cells.
research Non-Invasive Human Skin Transcriptome Analysis Using mRNA in Skin Surface Lipids
A new non-invasive method can analyze skin mRNA to understand skin diseases better.
research Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin
DGAT1 enzyme is crucial for healthy skin and hair by regulating retinoid levels.
research MicroRNA/mRNA Regulatory Networks in the Control of Skin Development and Regeneration
MicroRNAs are crucial for controlling skin development and healing by regulating genes.
research Transient Treatment of Pregnant Merino Ewes with Modulators of Cortisol Biosynthesis Coinciding with Primary Wool Follicle Initiation Alters Lifetime Wool Growth
Altering maternal cortisol during pregnancy can improve wool growth in Merino sheep.
research New Potential Antiscarring Approaches
New antiscarring strategies show promise, including drugs, stem cells, and improved surgical techniques.
research Epidermal Stem Cells: Practical Perspectives and Potential Uses
Epidermal stem cells could lead to new treatments for skin and hair disorders.
research Hormonal Regulation of Hair Follicles Exhibits a Biological Paradox
Androgens can both stimulate and cause hair loss, and understanding their effects is key to treating hair disorders.
research Comparing Current Therapeutic Modalities of Androgenic Alopecia: A Literature Review of Clinical Trials
Some treatments for hereditary hair loss are effective but vary in results and side effects; new therapies show promise but need more research.
research Comprehensive Analysis of LncRNA AC010789.1 Delays Androgenic Alopecia Progression by Targeting MicroRNA-21 and the Wnt/β-Catenin Signaling Pathway in Hair Follicle Stem Cells
The LncRNA AC010789.1 slows down hair loss by promoting hair follicle growth and interacting with miR-21 and the Wnt/β-catenin pathway.
research Impact of Adipose-Derived Stem Cells on Engineering Hair Follicle Germ-Like Tissue Grafts for Hair Regenerative Medicine
Adding human fat-derived stem cells to hair follicle grafts greatly increases hair growth.
research Towards a Molecular Understanding of Hair Loss and Its Treatment
Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.
research Hairless and Wnt Signaling: Allies in Epithelial Stem Cell Differentiation
The HR protein's role as a repressor is essential for controlling hair growth.
research Application of Multi-Omics Techniques to Androgenetic Alopecia: Current Status and Perspectives
Multi-omics techniques help understand the molecular causes of androgenetic alopecia.
research Rhamnose-Mediated Modulation of Hair Follicle Growth: Insights from Chemical Genomics
Rhamnose may help hair growth and pigmentation, making it a potential treatment for hair loss.
research Impact of Substrate Stiffness on Dermal Papilla Aggregates in Microgels
Softer hydrogel surfaces help maintain hair growth-related functions in skin cells.
research Hair Follicle Stem Cells: Walking the Maze
Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.
research Therapeutic Strategies for Treating Hair Loss
The conclusion is that we need more effective hair loss treatments than the current ones, and these could include new drugs, gene and stem cell therapy, hormones, and scalp cooling, but they all need thorough safety testing.
research The Roles of Non-Coding RNA in the Development and Regeneration of Hair Follicles: Current Status and Further Perspectives
Non-coding RNAs are important for hair growth and could lead to new hair loss treatments, but more research is needed.
research Inherited Epidermolysis Bullosa: Clinical and Therapeutic Aspects
The document concludes that inherited epidermolysis bullosa is a challenging genetic condition requiring multidisciplinary care and new treatments.