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270-300 / 1000+ resultsresearch Regulation of Involucrin Gene Expression
This review discusses the regulation of involucrin gene expression, focusing on transcription factors and signaling pathways, and reports no new experimental findings.
research Quantification of the Vitamin D Receptor−Coregulator Interaction
This study found that both the natural ligand 1alpha,25(OH)(2)D(3) and the synthetic agonist LG190178 bind similarly to the vitamin D receptor's coregulator motifs, suggesting similar biological functions.
research Effect of the frequency of injection on the clinical responses of postmenopausal women to testosterone enanthate with estradiol valerate
This study found that a single 2 ml injection of TEEV every 4 weeks offers similar beneficial effects with fewer side effects compared to injecting the same dose every 2 weeks in postmenopausal women.
research 3D cell culture stimulates the secretion of in vivo like extracellular vesicles
This study found that extracellular vesicles derived from 3D cultures of cervical cancer cells have small RNA profiles more similar to those in patient plasma than those from 2D cultures.
research Hypaphorine, an indole-3-acetic acid antagonist delivered by the ectomycorrhizal fungus Pisolithus tinctorius , induces reorganisation of actin and the microtubule cytoskeleton in Eucalyptus globulus ssp bicostata root hairs
This study found that hypaphorine alters cytoskeletal organization in Eucalyptus globulus root hairs, contributing to reduced root hair elongation by possibly disrupting vesicle delivery needed for growth.
research 15485 Evaluating the safety and efficacy of intense pulsed light with radiofrequency in US patients with hidradenitis suppurativa: A split-body study
Intense pulsed light with radiofrequency showed mixed results in improving quality of life for hidradenitis suppurativa patients, with no clinical improvements.
research Updates in Vitiligo
New treatments for vitiligo, including the first FDA-approved option, are improving patient care and quality of life.
research Effect of Orostachys iwarenge Hara on the proliferation of dermal papilla ceIls
This study suggests that Orostachys iwarenge extract may promote hair growth by increasing the proliferation of dermal papilla cells in an in-vitro setting.
research A microscopy-based small molecule screen in primary neurons reveals neuroprotective properties of the FDA-approved anti-viral drug Elvitegravir
This study reports that Elvitegravir, a drug currently approved for other uses, shows potential as a neuro- and mitoprotective agent by attenuating mitochondrial damage caused by NMDA receptors in primary mouse cortical neurons.
research Enhancement of therapeutic potential of mesenchymal stem cell by IGF-1 delivery in PLGA microspheres for tissue regeneration
This study found that using uniform poly(lactic-co-glycolic) acid microspheres to deliver insulin-like growth factor 1 stabilizes the protein and enhances its sustained delivery, supporting stem cell functions comparably to traditional methods, and showing potential for tissue and organ regeneration.
research IV Międzynarodowe Sympozjum Studenckich Kół Naukowych Środowisko – Roślina – Zwierzę – Produkt Streszczenia
Custom skincare can be made based on genes, fewer cats in Lublin have FeLV/FIV than national average, and studies also looked at small water bodies, river pollution, guppy growth, toxins in biochars, palm oil issues, and pumpkin seed oil for hair strength.
research 1112 An innovative phase 1b trial demonstrating proof-of-pharmacology for two novel IRAK4-inhibitors using a local (Imiquimod) and systemic (LPS) driven immune response
This study found that the oral IRAK4-inhibitors BAY 1834845 and BAY 1830839 reduced skin inflammation and systemic inflammatory responses in healthy volunteers, showing similar pharmacodynamic effects to prednisolone when challenged with topical imiquimod and intravenous LPS.
research Using microneedling in the treatment of vitiligo
This study suggests that microneedling may be an effective and less painful treatment for vitiligo, offering benefits over traditional needle injections, particularly in challenging-to-treat areas like the extremities or stubborn regions.
research 11. Accelerated UIP: a special challenge
This case study highlights the difficulties in diagnosing and treating interstitial lung disease, emphasizing the complex nature of ILD management and the need for further research and clearer guidelines.
research Incidence of androgenic dermatologic side effects following placement of a levonorgestrel intrauterine device for menorrhagia: A survey-based study
This letter highlights that levonorgestrel intrauterine devices may lead to fewer systemic side effects, like acne, compared to its oral administration due to lower systemic levels of progestogens.
research LB1256 TRIV-509, a dual inhibitor of KLK5 and KLK7, rapidly improves barrier integrity and markers of epidermal differentiation in atopic dermatitis skin explants
TRIV-509 quickly improves skin barrier and cell health in atopic dermatitis.
research Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages
This study suggests that mouse lineage specification during pre-implantation development involves distinct timing and mechanisms for trophectoderm and inner cell mass differentiation, challenging existing models.
research The regenerative wound healing effects and molecular mechanism of Isaria cicadae Miquel rice fermentation extract
This study suggests that Isaria cicadae Miquel rice fermentation extract may enhance regenerative wound healing of hair follicles in mouse skin through the Hippo pathway mechanism.
research FDA declines approval of testosterone drug for third time
This report discusses the FDA's rejection of Aveed, a long-acting testosterone injection, due to safety concerns despite divided advisory committee opinions, without presenting new clinical data.
research Cepharanthine inhibits enterovirus entry by endolysosomal deacidification and exhibits protective activity in vivo
This study found that cepharanthine may be a promising treatment for enterovirus infections, as it offered full protection to mice against lethal EV71 challenges and reduced viral titers and pathology.
research EXERCISE-INDUCED EXTRACELLULAR VESICLES DELAY TUMOR DEVELOPMENT VIA IGNITING THE INFLAMMATION IN THE IMMUNOLOGICALLY COLD BREAST CANCER MODEL
This preclinical study found that exercise-induced extracellular vesicles delayed breast cancer tumor growth in mice, potentially by enhancing the immune response within the tumor microenvironment.
research Bicalutamide
research Development, Characterization of Herbal Emulgel Containing Piper Betle Leaf Extract with In Vivo Studies
This study evaluated a Piper betle leaf emulgel for topical use and found it to have good stability, non-irritant properties, and significant hair growth activity in albino mice, suggesting its potential for dermatological and hair growth applications.
research SnapshotDx Quiz: May 2020
This study reported that specific inhibition of the classical complement pathway with BIVV009 prevented C3 deposition along the dermal-epidermal junction in bullous pemphigoid, reflecting its potential efficacy.
research Effects of depot medroxyprogesterone acetate, the copper IUD and the levonorgestrel implant on testosterone, sex hormone binding globulin and free testosterone levels: ancillary study of the ECHO randomized clinical trial
This study found that free testosterone levels were 29% higher with the levonorgestrel implant than with the DMPA injection, which may impact sexual function, mood, and side effects like acne.
research Discoid lupus erythematosus successfully treated with deucravacitinib
This review discusses current treatments for discoid lupus erythematosus and highlights anifrolumab as a promising option for difficult cases, but no new clinical results are reported.
research Therapeutic potential of extracellular vesicles derived from Platycladus Orientalis leaf in treating anxiety, depression, and insomnia
This study suggests that P. orientalis leaf-derived EVs could offer anxiolytic, antidepressant, and sleep-inducing benefits by affecting neurotransmitter levels and reducing inflammation, particularly when administered intranasally.
research USE OF IVERMECTINE AS TOPICAL APPLICATION IN TREATMENT OF RABBIT MANGE
This study found that topical Ivermectin 0.1% was the most effective treatment for rabbit mange among the tested options, achieving 100% survival, no persistent skin scales, and significant body weight changes, while topical cebacil gel resulted in 100% mortality and should not be used.
research Hafnium Oxide Nanostructure-Integrated Silk Fibroin Microneedles Reshape Cutaneous Melanocyte Microenvironment for Vitiligo Therapy
This study developed and tested a novel microneedle treatment loaded with nanoparticles for vitiligo, leading to enhanced skin repigmentation by targeting immune cells and reducing oxidative stress in a minimally invasive manner.