The Regenerative Wound Healing Effects and Molecular Mechanism of Isaria Cicadae Miquel Rice Fermentation Extract

February 2025 in “ Applied Microbiology and Biotechnology ”

Qin Wang, Wenwen Hao, Chao Guo, Hui Cao, B Wang, Xingyang Li, Ruilian Yu, Li Xu, Jing Li

Isaria cicadae Miquel rice fermentation extract IMFRE hair follicle regeneration CK15 CD34 EGFR GPCR Integrin Hippo pathway

TLDR Isaria cicadae Miquel rice fermentation extract helps heal wounds and regenerate hair follicles.

The study investigates the regenerative wound healing effects of Isaria cicadae Miquel rice fermentation extract (IMFRE) on skin, particularly focusing on hair follicle regeneration. The research highlights that IMFRE significantly enhances the wound healing rate in mouse skin and increases the expression of CK15 and CD34, which are markers associated with hair follicle regeneration. Additionally, IMFRE was found to inhibit the expression of EGFR, GPCR, and Integrin, suggesting its potential as a solution for regenerative wound healing through the Hippo pathway regulatory mechanism.

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