Enhancement of Therapeutic Potential of Mesenchymal Stem Cells by IGF-1 Delivery in PLGA Microspheres for Tissue Regeneration
March 2024
in “
Regenerative Therapy
”
Studysummary This study found that using uniform poly(lactic-co-glycolic) acid microspheres to deliver insulin-like growth factor 1 stabilizes the protein and enhances its sustained delivery, supporting stem cell functions comparably to traditional methods, and showing potential for tissue and organ regeneration.
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This study explores a biomaterial strategy using uniform poly(lactic-co-glycolic) acid (PLGA) microspheres (uPLGA-Ms) for the sustained delivery of insulin-like growth factor 1 (IGF-1) to enhance the regenerative capabilities of human mesenchymal stem cells (hMSCs). The uPLGA-Ms were fabricated using microfluidics to ensure precise and monodispersed delivery of IGF-1. The results indicate that this method stabilizes IGF-1 and provides a more efficient and cost-effective delivery compared to traditional methods. Gene expression analysis showed that the uPLGA delivery of IGF-1 supports hMSCs expansion, survival, stemness, and secretion abilities, making this approach promising for tissue and organ regeneration.
