Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Enhance Acellular Nerve Allografts to Promote Peripheral Nerve Regeneration by Facilitating Angiogenesis

September 2024 in “ Neural Regeneration Research ”

Fan-Qi Meng, Chaochao Li, Wenjing Xu, Junhao Deng, Yanjun Guan, Tieyuan Zhang, Boyao Yang, Jian Zhang, Xiangling Li, Feng Han, Zhi-Qi Ren, Shuai Xu, Yan Liang, Wen Jiang, Jiang Peng, Yu Wang, Haiying Liu

Studysummary This study found that using induced pluripotent stem cell-derived mesenchymal stem cells with acellular nerve allografts significantly improved axon regeneration and functional recovery in rats with sciatic nerve injuries, suggesting a promising approach for clinical nerve repair therapies.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer ·

View this study on journals.lww.com →

Discuss this study in the Community →

Similar Research

5 / 1000+ results

research Getting to the Core of the Dermal Papilla

21 citations , October 2017 in “Journal of Investigative Dermatology”

This review discusses recent advances in understanding the molecular landscape of the dermal papilla, particularly focusing on Blimp1's role in hair follicle development and potential therapeutic targets for hair regeneration, but presents no new clinical results.

research Effects of oxytocin on the hair growth ability of dermal papilla cells

October 2023 in “Scientific Reports”

This study explored the effects of oxytocin on hair growth and found that it upregulated growth-promoting factors in dermal papilla cells and hair follicle organoids, suggesting potential for developing new alopecia treatments.

research Use of Exosomes for Cosmetics Applications

January 2025 in “Cosmetics”

In this study, a systematic review highlighted the potential of exosomes in cosmetics and regenerative medicine for improving skin rejuvenation and addressing aging, while also pointing out existing challenges such as regulatory hurdles and the need for more clinical validation.

Glypican-1, -4, and -6 Participate in Hair Follicle Stem Cell Differentiation via Specific Interactions with BMP2R, Fz7, and Patched 1

research Glypican-1, -4 and 6 Participate in the Hair Follicle Stem Cell Differentiation via Specific Interactions with BMP2R, Fz7 and Patched 1

October 2024 in “SPIRE - Sciences Po Institutional REpository”

This study highlights that human hair follicle dermal papilla cells and glypicans play crucial roles in regulating hair follicle stem cell differentiation.

research In vitro hair follicle growth model for drug testing

3 citations , March 2023 in “Scientific Reports”

This study found that organoid cultures of human epithelial and mesenchymal cells can produce hair peg-like structures, and their growth is enhanced by minoxidil, suggesting potential for hair drug screening.