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Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Calreticulin has roles in healing, immune response, and disease beyond its known functions in the endoplasmic reticulum.

Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

The document concludes that the understanding of scar formation is incomplete and current prevention and treatment for hypertrophic scars and keloids are not fully effective.

The conclusion is that certain cell interactions and signals are crucial for hair growth and regeneration.

The conclusion is that using drugs to block the TOR pathway might slow aging and prevent age-related diseases.

Treatments that reduce oxidative stress and fix mitochondrial problems may help heal chronic wounds.

Epithelial-mesenchymal interactions control hair growth cycles through specific molecular signals.

Removing part of the vitamin D receptor stops vitamin D from working properly.

Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

The immune system plays a key role in tissue repair, affecting both healing quality and regenerative ability.

Melatonin in the skin helps protect against damage from stress and UV rays, and could be used to treat certain skin conditions.

Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.

Human skin can make serotonin and melatonin.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Finasteride doesn't effectively treat hair loss in postmenopausal women.

Blocking the enzyme 5α-reductase can shrink the prostate and help treat enlarged prostate issues.

BAY 43-9006 helps control kidney cancer growth but doesn't significantly increase overall survival.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

Knowing about finasteride's sexual side effects increases reported dysfunction.

The document concludes that understanding hair follicle biology can lead to better hair loss treatments.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

Melatonin is important for skin health and protection, and can be made by the skin or applied to it.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Overexpression of activin A in mice skin causes skin thickening, fibrosis, and improved wound healing.

Lactate production is important for activating hair growth stem cells.

Artificial skin development has challenges, but new materials and understanding cell behavior could improve tissue repair. Also, certain growth factors and hydrogel technology show promise for advanced skin replacement therapies.

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

A gene called APCDD1, which controls hair growth, is found to be faulty in a type of hair loss called hereditary hypotrichosis simplex.

Sebocytes play a key role in controlling androgen levels in human skin.