61 citations
,
June 2018 in “Proceedings of the National Academy of Sciences of the United States of America” This study found that light stimulation of intrinsically photosensitive retinal ganglion cells in the eyes can activate hair follicle stem cells through a neural circuit involving the sympathetic nervous system.
57 citations
,
March 2021 in “International Journal of Molecular Sciences” This study found that type 2 immunity may play a role in the development of alopecia areata in patients with extrinsic atopic dermatitis, indicating different immunological states compared to non-atopic patients.
33 citations
,
April 2005 in “British Journal of Dermatology” This study found that age and follicular miniaturization were extremely weak predictors of total hair count in women with hair loss.
31 citations
,
December 2012 in “British Journal of Dermatology” This study found that as Korean women age, their hair density, diameter, tensile strength, and lustre decline, while grey hair ratio and certain sterol contents increase, suggesting unique ageing features compared to women in other countries.
24 citations
,
January 2006 in “Dermatologic clinics” This review discusses the chemical effects of UV radiation on hair, hair photoaging, and photoprotective measures, and calls for more focused research in hair photoprotection as a field.
21 citations
,
January 1995 in “Molecular Biology Reports” This study identified a novel human type I hair keratin, hHa3-II, as an isoform of a previously described hHa3 keratin, with distinct sequence differences indicating separate gene encoding.
17 citations
,
April 2006 in “Dermatologic Clinics” This review discusses common skin disorders in older women and their treatments, but it reports no new clinical results.
16 citations
,
July 2012 in “Current pharmaceutical biotechnology” This review discusses the pathogenesis of common sebaceous gland diseases and their molecular pathways, but it reports no new clinical findings.
12 citations
,
August 2022 in “Biochemical Journal” This review discusses the mechanisms of skin-associated cell death and their potential role in treating inflammatory skin diseases, but presents no new clinical findings.
8 citations
,
November 2017 in “PubMed” This article discusses common underlying mechanisms across hair loss disorders, emphasizing the role of inflammation, but reports no new clinical results.
1 citations
,
January 2025 in “Anais Brasileiros de Dermatologia” This study conducted a narrative review of literature to identify non-pharmacological treatment solutions and strategies that might mitigate the negative impact of the exposome—factors like UV radiation, pollution, and lifestyle choices—on hair health.
1 citations
,
August 2024 in “PubMed” This study demonstrated that carboxytherapy significantly increased epidermal and dermal thickness, improved collagen and elastin organization, and enhanced expression of TGF-β1 and VEGF in older skin.
1 citations
,
January 2021 in “Research, Society and Development” This study reviewed literature on using vegetable oils to prevent skin aging, highlighting their antioxidant properties and their role in combating free radicals, which leads to extrinsic aging, while also noting Brazil's important contribution to this field with its rich natural resources.
1 citations
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December 2005 in “Therapeutische Umschau” This article reviews anti-aging strategies in dermatology, emphasizing the role of skin as a model for studying aging and promoting preventive and therapeutic interventions, but it does not present new findings.
February 2026 in “Frontiers in Medical Technology” This review discusses current knowledge of keratinocyte stem cell dynamics, including their regenerative roles and potential applications beyond wound healing, but presents no new clinical findings.
September 2025 in “Biomolecules” This review analyzed the complex interactions within the skin microenvironment that influence hair follicle development and regeneration, exploring its role in hair-related disease treatment and highlighting research challenges and future directions.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This review explores the multifaceted roles of melanocytes in skin biology, emphasizing their potential impact on future research to prevent and treat skin diseases, but reports no new experimental results.
April 2023 in “Journal of Investigative Dermatology” In this study, researchers observed distinct aging signatures in mouse keratinocytes, with increased expression in older mice, and noted relevant pathway changes that were also evident in human skin, suggesting potential insights into intrinsic skin aging.
June 2020 in “International Journal of Research in Dermatology” In this study, xerosis was the most common skin condition found among elderly participants, followed by wrinkling and immunoglobulin heavy chain deposition.
April 2018 in “Journal of Investigative Dermatology” This study found that external light can rapidly activate hair follicle stem cells in animals via a retinal light-sensing pathway linked to the central and autonomic nervous systems.
August 2016 in “Journal of Investigative Dermatology” This case report identifies a novel LIPH gene mutation linked to autosomal recessive woolly hair/hypotrichosis in a Japanese boy, expanding the spectrum of known mutations associated with this condition.
April 2014 in “Journal of evolution of medical and dental sciences” This article reviews the skin and hair changes associated with menopause due to hormonal shifts and reports no new clinical results.
May 2013 in “Springer eBooks” Skin problems in the elderly are unique and may indicate other diseases, involving changes in skin, hair, nails, and increased cancer risk.
February 2008 in “Experimental dermatology” This article reviews potential pathomechanisms of vitiligo, emphasizing membrane alterations involving cholesterol and cardiolipin, but reports no new clinical findings.
15 citations
,
November 2009 in “Journal of diabetes and its complications” This case highlights the potential link between type 1 diabetes, pernicious anemia, and alopecia areata universalis, suggesting clinicians should monitor for pernicious anemia in such patients.
1 citations
,
May 2021 in “Cell Host & Microbe” This study reports that skin bacteria can accelerate hair follicle regeneration and improve wound healing through IL-1β signaling, by activating keratinocytes in a pathway involving IL1R/Myd88.
November 2020 in “Journal of Pharmaceutical Sciences” This study suggests a decision tree using in vitro metabolic clearance to identify early drug candidates likely to experience nonlinear pharmacokinetics due to intestinal CYP3A-related metabolism.
12 citations
,
January 2000 in “Biochemical and Biophysical Research Communications” This study characterized the intron-exon organization of human keratin 15 and keratin 19 genes to aid future mutation detection analyses related to potential genetic disorders of keratinization.
18 citations
,
January 2017 in “Dermatologic Surgery” This review examines intrinsic and extrinsic aging impacts and presents evidence-based lifestyle recommendations to complement cosmetic procedures for enhanced antiaging outcomes, but it reports no new clinical results.
This study found that intrinsic feedback loops are crucial for maintaining the function of human dermal papilla cells during hair growth, highlighting the importance of autocrine signaling and niche reprogramming for advancing hair follicle biology and regenerative therapies for hair loss.