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The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Melatonin is important for skin health and protection, and can be made by the skin or applied to it.

Tiny pollution particles called PM2.5 can harm skin cells by causing stress, damage to cell parts, and cell death.

Noggin is necessary to start the hair growth phase in skin after birth.

Essential oils in cosmetics can offer benefits but may cause allergies and should be used carefully.

Women with PCOS have heart-related issues not because of obesity, but due to insulin resistance and low adiponectin levels.

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.

The document recommends using both clinical evaluation and various measurement methods to assess skin greasiness, considering factors like temperature and hormones.

Hair analysis can detect cocaine use but doesn't accurately show the amount or timing of use.

Fat cells in the skin help start healing and form important repair cells after injury.

Women with PCOS are more than twice as likely to develop nonalcoholic fatty liver disease.

Dihydrotestosterone gel improved well-being and sexual function in older men without negatively affecting prostate health.

Choosing the right model order in brain connectivity analysis can affect the detection of differences between healthy individuals and those with seasonal affective disorder.

Melatonin helps regulate hair growth and protects the hair follicle from stress.

Fetal wound healing changes with development, affecting inflammation and collagen, which may influence scarring.

Preoperative pain assessment, regional anesthesia, and vitamin C can help prevent CRPS after surgery.

Flutamide may slightly improve hair loss in women, but finasteride does not work.

New single-cell analysis techniques are improving our understanding of stem cells and could help in treating diseases.

The document concludes that assessing hair follicle damage due to cyclophosphamide in mice involves analyzing structural changes and suggests a scoring system for standardized evaluation.

DHT may increase the risk of heart disease and death in elderly men.

Treating psoriasis on the scalp, nails, and skin folds is challenging, often requiring systemic treatments for severe cases, with some success in topical and biologic treatments.

A three-month treatment with a GnRH agonist significantly lowered androgen levels and 5α-reductase activity in men with benign prostatic hyperplasia.

Dutasteride and finasteride do not significantly affect bone density, blood fats, or blood production, but slightly lower PSA levels and minimally impact sexual function in healthy young men.

mTOR signaling helps activate hair stem cells by balancing out the suppression caused by BMP during hair growth.

Oxidative stress is a key factor in the development of Polycystic Ovary Syndrome, and weight management can improve symptoms.

Finasteride almost fully depletes allopregnanolone in rat brains and enhances 20α-DHP, but doesn't change 3α-DHP levels.

Cyclosporin is effective for treating skin conditions in small animals, but requires careful dosing and monitoring for side effects.

Reconstruct lips with proper planning, templates, and revisions for appearance and function.

Patients with Bohring-Opitz syndrome and ASXL1 mutations need regular kidney ultrasounds to check for tumors.

Botulinum toxin shows promise for various skin conditions but requires more research for confirmation and standardized use.