23 citations
,
January 1986 This review discusses the chemical stability of protein envelopes found in the epidermis and other stratified squamous epithelia, but reports no new clinical results.
January 2025 in “British Journal of Dermatology” This study proposes that the ability of humans to grow long scalp hair is linked to the evolutionary adjustment of molecular checkpoints that regulate the hair growth cycle, potentially influenced by its roles in communicating age, maturity, and social signals.
6 citations
,
January 2009 in “Elsevier eBooks” This chapter discusses the structure and function of the skin, detailing its protective roles and the layers that comprise it, but reports no new research findings.
33 citations
,
October 2012 in “Journal of Morphology” This study identified the distribution of keratin-associated proteins during cornification in the epidermis of reptiles, revealing unique structural characteristics in sauropsid keratin proteins compared to other vertebrates.
112 citations
,
August 1984 in “Journal of Investigative Dermatology” 130 citations
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February 2005 in “Proceedings of the National Academy of Sciences” This study found that differentiated cells of the corneal epithelium can be converted to hair and interfollicular epidermis through a multistep process involving dermal developmental signals.
April 2023 in “Journal of Investigative Dermatology” This study identified ectomesenchyme as a major source of epidermal stem cells in mouse skin, with ectomesenchymal keratinocytes occupying a significant portion of the epidermal stem cell-enriched population.
7 citations
,
October 2019 in “Elsevier eBooks” This chapter defines skin integrity as a blend of intact structural elements and adaptable functional capacity, highlighting its importance in maintaining skin health across various conditions but reports no new research findings.
November 2022 in “Journal of Investigative Dermatology” This study demonstrated that hiPSC-derived hair-bearing skin organoids lacked sufficient type VII collagen at the epidermal-dermal junction, indicating a need for further maturation to model certain forms of epidermolysis bullosa effectively.
10 citations
,
May 1994 in “Journal of Investigative Dermatology” January 2009 in “Elsevier eBooks”
19 citations
,
April 2019 in “Journal of the European Academy of Dermatology and Venereology” This study found that acne lesion formation involves early hyperkeratinization and inflammation around hair follicles, creating a self-sustaining cycle that may progressively worsen acne.
April 2023 in “Journal of Investigative Dermatology” This study demonstrates that human epidermal stem cells can adapt to environmental temperature changes through mTOR signaling, and prolonged inhibition of mTORC1 supports stem cell maintenance, which may be vital for regenerative medicine.
28 citations
,
April 1996 in “Cell biology international” This review discusses changes in keratin structure or gene expression that result in various skin disorders and reports no new clinical findings.
21 citations
,
September 2005 in “The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology/Anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology” This study reports that caspase-14's expression pattern in the epidermis and hair follicles is highly conserved across diverse mammalian species, suggesting its early evolutionary role in mammalian skin maturation.
34 citations
,
January 1983 in “Journal of Investigative Dermatology”
13 citations
,
April 2022 in “Frontiers in oncology” This review discusses the early phases of melanomagenesis and the factors influencing melanoma cell variability and reports no new clinical results.
103 citations
,
April 2010 in “Journal of Investigative Dermatology” This study reports that human eccrine sweat gland cells are capable of forming a stratified epidermis, suggesting they may serve as an additional source of keratinocytes for skin repair.
26 citations
,
December 2013 in “Seminars in cell & developmental biology” This article reviews how anatomical differences in skin arise and persist, and suggests the underlying molecular positional code is more complex than apparent, but reports no new research findings.
118 citations
,
January 2004 in “European Journal of Cell Biology” Balanced protease activity is crucial for healthy skin and hair development.
January 2007 in “Zhonghua shiyan waike zazhi” This study found that cutaneous stem cells in the basal layer of fetal human skin contribute to the development of the epidermis and hair follicles, with specific marker expressions during different stages of skin development.
5 citations
,
February 2014 in “PloS one” This study reports differential gene expression in the leading edge and inner surface epithelial cells of murine eyelids, suggesting that distinct signaling pathways are active during embryonic eyelid closure.
221 citations
,
June 1999 in “In Vitro Cellular & Developmental Biology - Animal” April 2026 in “Development” This study found that loss of integrin-β4 or its ligand, laminin-α3β3ɣ2, in keratinocytes increases differentiation via delamination, and demonstrated a role for hemidesmosomes in epidermal differentiation through both mitotic and non-mitotic mechanisms, influenced by Notch signaling.
April 2018 in “Journal of Investigative Dermatology” This study used single-cell RNA sequencing to identify at least nine subpopulations of keratinocytes in human neonatal epidermis, revealing unexpected heterogeneity and complex differentiation trajectories.
6 citations
,
September 2013 in “The Obstetrician & Gynaecologist” This article reviews the physiological skin changes and unique dermatoses in pregnancy, discussing their causes and management, but reports no new clinical findings.
April 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study identifies key transcriptomic features and a necessary dermal niche for eccrine gland development, advancing potential regenerative approaches for these vital skin appendages.
65 citations
,
July 1984 in “Journal of Investigative Dermatology” In this study, autotransplanted interfollicular epidermis keratinocytes in a collagen dermis framework formed follicular-like structures, but their proliferation ceased after 15-20 days.
June 2017 in “Experimental dermatology” This article, a special issue on hair follicle biology and pathology, reports no new research findings.