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Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Calreticulin has roles in healing, immune response, and disease beyond its known functions in the endoplasmic reticulum.

Changing how mesenchymal stromal cells are grown can improve their healing abilities.

Fat tissue-derived cells show promise for repairing body tissues, but more research and regulation are needed for safe use.

The document concludes that the understanding of scar formation is incomplete and current prevention and treatment for hypertrophic scars and keloids are not fully effective.

The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

The conclusion is that proper signaling is crucial for hair growth and development, and errors can lead to cancer or hair loss.

Some herbal therapies may help with skin conditions, but more research is needed to confirm their safety and effectiveness.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

Periodontal ligament stem cells show promise for regrowing tissues but require more research for safe, effective use.

Fat-derived stem cells show promise for skin repair and reducing aging signs but need more research for consistent results.

Macrophages help heal nerves by aiding the maturation of Schwann cells and are important for nerve repair.

Early detection and intensive treatment of diseases caused by Staphylococcus aureus toxins are crucial for reducing severe health effects.

Smoking harms the skin, causing early aging and increasing cancer risk, but stopping smoking can improve skin health.

Men, especially older ones with health issues like prostate cancer, may have worse COVID-19 outcomes and could benefit from therapies targeting male hormones.

Formyl-peptide receptor agonists could be new anti-inflammatory drugs.

Recombinant cytokine therapy can cause skin reactions ranging from mild to severe.

Pure carbon nanotubes are safe for mice, but impure ones cause immune issues and hair loss.

The document concludes that certain genetic mutations and dietary factors are involved in acne development, and treatments like isotretinoin and diet changes can help manage it.

Hormones and metabolism play a complex role in prostate enlargement, and more research is needed to improve diagnosis and treatment.

The document concludes that dandruff and seborrheic dermatitis are linked to inflammation and skin changes, and treating them with specific shampoos can reduce these issues.

Alopecia areata is likely caused by a combination of genetic factors and immune system dysfunction, and may represent different diseases with various causes.

PDRN helps repair tissue and improve wound healing with a high safety profile.

Vitiligo affects overall health and self-esteem, needing more research and awareness.

Human skin cells produce proenkephalin, which changes with environmental factors and skin diseases.

Both vitiligo and alopecia areata involve an immune response triggered by stress and specific genes, with treatments targeting this pathway showing potential.

Women with PCOS have different levels of certain fats and proteins in their blood, which could help diagnose the condition.

People with diabetes or obesity should manage their conditions carefully as they have a higher risk of severe COVID-19.

Macrophages are vital for skin healing, hair growth, salt balance, and cancer defense.

Fat from the body can help improve hair growth and scars when used in skin treatments.