November 2024 in “Journal of Investigative Dermatology” Inherited ichthyosis negatively impacts quality of life, affecting daily activities, self-image, and reproductive decisions.
This report describes a rare case of kerion in a 6-year-old boy in Ireland, treated with oral Itraconazole and steroids, highlighting the condition's unusual occurrence in the region.
55 citations
,
April 2008 in “Clinical Genetics” This report identifies a novel mutation in the ST14 gene in a female with autosomal recessive ichthyosis with hypotrichosis, highlighting similar features to previously reported cases.
October 2023 in “Applied sciences” In this study, Iris germanica L. rhizome-derived exosomes were found to reduce oxidative stress, enhance antioxidant enzyme transcription, and restore cellular function in human epidermal keratinocytes, suggesting potential protective effects against oxidative-stress-induced skin damage.
6 citations
,
June 2022 in “Frontiers in Bioengineering and Biotechnology” This study found that a hydrogel containing icariin enhanced wound healing and hair-follicle regeneration in vivo by promoting M2 macrophage polarization and modulating the BMP pathway, with treated skin defects showing improved recovery and new hair follicle development compared to untreated defects.
April 2026 in “International Journal of Homoeopathic Sciences” In this case report, individualized homeopathic treatment based on symptom totality led to anxiety reduction, halted lesion progression, and complete cosmetic recovery in a 30-year-old male with alopecia areata barbae, highlighting a potential area for further controlled studies.
August 2024 in “International Journal of Women’s Dermatology” This study characterizes alopecia in ARCI, highlighting its prevalence among patients with severe forms and revealing new associated trichoscopic features.
July 2026 in “Frontiers in Immunology” In this case report, a 28-year-old male with severe atopic dermatitis, prurigo nodularis-like lesions, and alopecia areata showed rapid improvements in skin and hair following treatment with the JAK1 inhibitor, ivarmacitinib, suggesting its potential benefit for complex AD phenotypes with immune-mediated hair loss.
2 citations
,
June 2023 in “Journal of cell science” In this study, researchers found that specific mutations in iRhom2 in mice lead to skin and hair abnormalities which depend on the presence of the protein ADAM17, suggesting a complex role for iRhom2 in tissue development and potential implications for treating tylosis with oesophageal cancer.
November 2023 in “Frontiers in pharmacology” This review highlights the ongoing need for novel treatments for autosomal recessive congenital ichthyoses, suggesting that drug repositioning, utilizing existing medications or biologics, could provide more affordable and effective options for managing this lifelong skin condition.
9 citations
,
August 2020 in “International Journal of Molecular Sciences” This review examines compounds that activate IK1 channels, highlighting their potential for developing Kir channel agonists and addressing safety concerns, but does not report new experimental findings.
This study found that activating KATP channels with pinacidil may reduce antioxidant levels and mortality in honey bees, suggesting a role in regulating antiviral immunity through reactive oxygen species.
April 2025 in “Indian Dermatology Online Journal” This study describes how avian-inspired imagery is used in dermatology to help clinicians and patients identify and communicate skin conditions, using familiar terms like "chicken skin" and "fried egg" to capture specific visual patterns and clinical features.
September 2025 in “Radboud University Press eBooks” This study investigated AHR signaling's role in skin biology and reported that novel AHR ligands may help restore keratinocyte function and reduce inflammation in skin diseases, suggesting their potential as therapeutic agents.
10 citations
,
July 2011 in “Springer eBooks” This review describes the use of carbon dioxide for aesthetic treatments like skin rejuvenation and scar reduction but does not present new clinical findings.
34 citations
,
June 1992 in “Journal of Cutaneous Pathology” In this case study, electron microscopy revealed that harlequin ichthyosis involves giant mitochondria in keratinocytes and abnormal lamellar granule development, which may contribute to pathogenesis through altered lipid metabolism.
November 2025 in “SKIN The Journal of Cutaneous Medicine” In this phase 3 trial, baricitinib showed effectiveness and safety in both adolescents and adults with severe alopecia areata, with adolescents achieving higher response rates despite more severe baseline conditions, suggesting the advantages of early treatment.
January 2026 in “Frontiers in Immunology” This review highlights icariin’s potential to regulate macrophages in varying conditions, discussing its effects on macrophage polarization, metabolism, and disease mechanisms, and noting the development of delivery systems to enhance its therapeutic impact.
8 citations
,
April 2024 in “Cureus” This review compares the CO2 and Er:YAG laser treatments for acne scars, noting that while CO2 lasers offer deeper tissue penetration for severe scars, Er:YAG lasers pose a lower risk of post-inflammatory hyperpigmentation, and recommends personalizing treatments and considering combination therapies.
August 2022 in “Journal of Investigative Dermatology” Baricitinib reduces inflammation and mitochondrial damage in skin cells.
January 2025 in “Current Allergy and Asthma Reports”
1 citations
,
January 2021 in “Wiadomości Lekarskie” This experimental study on male rats found that a gel containing carbon dioxide extract of hops effectively promoted wound healing in severe acne by enhancing skin regeneration and exhibiting anti-inflammatory, bactericidal, and antimycotic properties.
11 citations
,
January 2021 in “British Journal of Dermatology” This report describes a new case of syndromic ichthyosis caused by compound heterozygous mutations in AP1B1, detailing the associated clinical features and molecular consequences in the patient.
April 2023 in “Journal of Investigative Dermatology” In this study, the KPAI and KP-IGA scoring systems for assessing keratosis pilaris showed excellent interrater and intrarater reliability, offering standardized measures for clinical and research use.
January 2022 in “Turkiye Klinikleri Journal of Dermatology” This study found that the Turkish version of the Multidimensional Assessment of Interoceptive Awareness-2 Scale is valid and reliable for use with Turkish dermatology patients.
11 citations
,
January 2010 in “Current problems in dermatology” Ichthyoses are genetic skin disorders that affect the skin's barrier function.
November 2022 in “Journal of Investigative Dermatology” This study found that the immunological characterization of ichthyoses as psoriasiform or atopic patterns could help improve treatment, highlighting the need for targeted therapies to address itch and skin inflammation.
13 citations
,
March 1997 in “Research in Veterinary Science/Research in veterinary science” This study found that epithelial keratin K 6 is associated with hyperkeratotic and ulcerated changes in the gastric pars oesophagea of pigs, suggesting epithelial proliferation plays a role in ulcer development.
March 2026 in “International Journal of Homoeopathic Sciences” This case report describes the improvement of papulo-pustular acne in a 27-year-old woman through individualized homoeopathic treatment with Kalium bromatum, placebo, and lifestyle advice, highlighting its potential usefulness in acne management.
36 citations
,
January 2000 in “British journal of dermatology/British journal of dermatology, Supplement” This case study reports on a mother and daughter with ichthyosis follicularis, alopecia, and photophobia, noting consistent keratotic eruptions during the mother's pregnancies that improved postpartum.