Alopecia Patterns and Trichoscopic Findings in Patients with Autosomal Recessive Congenital Ichthyosis

This study on 30 Tunisian patients with autosomal recessive congenital ichthyosis (ARCI) reveals significant alopecia patterns, including patchy alopecia and hairline recession, with a notable female predominance. Trichoscopic findings such as broken hair and interfollicular scaling correlate with ARCI severity. Molecular analysis identified TGM1 gene mutations in 13 of 15 tested patients. The research highlights the psychological impact on women and the importance of trichoscopy for diagnosis, suggesting early treatment to prevent irreversible alopecia. It calls for further research with larger cohorts to explore genotype-phenotype correlations.