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420-450 / 1000+ resultsresearch Identification of differentially expressed Gnαs and Gnα11 in sheep ( Ovis aries ) skins associated with white and black coat colors
This study found that Gnαs and Gnα11 proteins were significantly more expressed in the skin of black sheep compared to white sheep, suggesting their role in coat color regulation.
research THE IDENTIFICATION OF MOLECULAR MECHANISMS FROM BIOACTIVE COMPOUNDS IN Sansevieria trifasciata PLANT AS ANTI-ALOPECIA: In-Silico APPROACH
This study analyzed the affinity, stability, and pharmacokinetics of compounds from Sansevieria trifasciata, reporting that three compounds showed promising molecular docking results against the androgen receptor and satisfactory pharmacokinetic profiles, similar to minoxidil, in an in-silico setting.
research PIK3CA gain-of-function mutation in Schwann cells leads to severe neuropathy and aerobic glycolysis through a non-cell autonomous effect
In this study, a mouse model with a PIK3CA gain-of-function mutation in Schwann cells revealed unique communication with neighboring cells and a glycolytic shift in peripheral nerves, and early alpelisib treatment significantly improved symptoms, though efficacy declined with delayed administration due to limited drug penetration.
research Table S1. Disease-dependent differences between tape-strip and bulk biopsy ssGSEA scores across hair follicle compartments
This report presents gene set enrichment scores for hair follicle compartments using tape strip and bulk biopsy methods, providing statistical data but no new experimental findings.
research The HEDGEHOG-GLI1 pathway is important for fibroproliferative properties in keloids and as a candidate therapeutic target
This study found that inhibiting the HEDGEHOG-GLI1 pathway could reduce keloid size and gene expression, suggesting it as a potential therapeutic target for keloid pathogenesis.
research Ichthyoses
Ichthyoses are skin disorders causing scales, with treatment depending on type and severity.
research Solubilization and Solid‐State Characterization of a Poorly Soluble 5‐α Reductase Inhibitor
This study explored the solubility and crystal structure of GI197111X, a 5-alpha reductase inhibitor for androgenetic alopecia, finding its solubility in Capmul MCM suitable for a soft gel dosage form.
research Discovery and Optimization of Novel Pyridines as Highly Potent and Selective Glycogen Synthase Kinase 3 Inhibitors
This study reports that a novel series of compounds can potently and selectively inhibit glycogen synthase kinase-3, which activates glycogen synthase in insulin receptor-expressing cells and primary rat hepatocytes.
research Steroid plant hormones: Effects outside plant kingdom
This review suggests that brassinosteroids may have similar biological activities in both plants and other organisms, prompting further exploration of steroid regulation mechanisms across different life forms.
research Overexpression of mIGF-1 in Keratinocytes Improves Wound Healing and Accelerates Hair Follicle Formation and Cycling in Mice
mIGF-1 in skin cells speeds up wound healing and hair growth in mice without harmful effects.
research Hair growth-promoting effect of Geranium sibiricum extract in human dermal papilla cells and C57BL/6 mice
In this study, Geranium sibiricum L. extract promoted hair growth in vitro with human dermal papilla cells and in vivo in mice, outperforming minoxidil by proliferating cells and stimulating growth factor expression, suggesting its potential as a hair growth treatment.
research Social isolation‐induced increase in α4and δ subunit gene expression is associated with a greater efficacy of ethanol on steroidogenesis and GABAAreceptor function
This study found that social isolation in rats enhanced ethanol's effects on brain steroidogenesis and GABA A receptor function, altering related behavior more than in non-isolated rats.
research Table S1. Disease-dependent differences between tape-strip and bulk biopsy ssGSEA scores across hair follicle compartments
This table reports gene set enrichment analysis scores for hair follicle compartments across diseases and sampling methods, providing comparisons but no new experimental findings.
research Graham Little–Piccardi–Lassueur syndrome in a patient with androgen insensitivity syndrome
This article discusses a case of Graham Little–Piccardi–Lassueur syndrome in a patient with androgen insensitivity syndrome and reports no new research findings.
research Novel recombinant human acid α-glucosidase with optimal glycosylation is significantly better than standard of care enzyme replacement for glycogen clearance in skeletal muscles of GAA knock-out mice
research Editorial: Software survey section
research Selected abstracts from the 47th meeting of the Irish Endocrine Society Sligo, 24th & 25th November 2023
Continuous glucose monitoring and GLP-1 receptor agonists improve diabetes management, but personalized care and education are crucial.
research Dodatek A: Model matematyczny AL/RC/ASE. Functional Androgen Axis (FOA) - wersja operacyjna v1.2
In this study, Dodatek A operationalizes the Functional Androgen Axis framework by defining three system-level indices and an efficiency metric to describe androgen function, incorporating key methodological improvements and acknowledging significant limitations for future empirical validation.
research Self-assembling peptide inspired by insulin and type 1 insulin-like growth factor for the treatment of androgenetic alopecia
In a murine model of androgenetic alopecia, this study found that the newly designed IGF-1 biomimetic peptide Ac-GFFY-IGF led to faster and superior hair regrowth compared to minoxidil, suggesting potential for improved human therapies.
research 7288 A Preclinical Mouse Model of Gender-Affirming Hormone Therapy: Metabolic and Behavioral Outcomes
This study observed that gender-affirming hormone therapy differentially affects metabolism in mice, with the specific metabolic impacts dependent on the type of hormonal treatment used.
research A genetically informed brain atlas for enhancing brain imaging genomics
This study concluded that the GIANT brain atlas, which integrates genetic and neuroanatomical variations, provides a more accurate representation of brain structure than traditional neuroanatomical atlases, allowing for better exploration of genetic influences on the brain.
research Gap junctions in Turing-type periodic feather pattern formation
This study found that gap junctional communication influences feather patterning by modulating Turing-type activator-inhibitor systems in chicken skin, suggesting its role in propagating inhibitory signals crucial for pattern formation.
research Silver Oxide Based Nanoparticle Assisted Laser Desorption/Ionization Mass Spectrometry for the Detection of Low Molecular Weight Compounds
In this study, silver oxide-based nanoparticles were used to ionize analytes and detect specific target molecules through adduct formation with silver isotopes, facilitating signal correlation with these molecules.
research Efficacy of Sr2⁺ and Cu2⁺ Ion Incorporation on the Mechanical, biological, and antibacterial properties of natural waste-derived borosilicate bioactive glasses for orthopaedic implants
This study found that a bioactive borosilicate glass containing Sr and Cu ions exhibited promising mechanical strength, biocompatibility, and antibacterial activity, particularly the CuSr-1 wt.% composition, suggesting potential for use in orthopedic implants and bone tissue engineering.
research Chapter 17. Selective androgen receptor modulators (SARMs)
This chapter reviews selective androgen receptor modulators, discussing their therapeutic potential beyond current androgen applications, and reports no new clinical findings.
research A Shapable Alginate Hydrogel Resolving the Conflicts between Multifunctionality and Fabrication Simplicity
This study reports that the newly developed SA-Ca(II) hydrogel has tunable mechanical properties, high biocompatibility, and potential applications in wearable protections and stimuli-responsive electronics.
research Safety and efficacy of actinic keratoses reduction with a 3 day application of ingenol disoxate field treatment to the face, chest and balding scalp
This phase 2 trial found that SM04554, a Wnt signaling modulator, was well-tolerated and increased follicle counts in males with androgenetic alopecia, suggesting potential for promoting hair growth.
research Generation of comparative pharmacophoric model for steroidal 5α-reductase I and II inhibitors: A 3D-QSAR study on 6-azasteroids
This study generated a pharmacophoric model for both isoforms of steroidal 5α-reductase using 6-azasteroids, providing a structural framework for designing new inhibitors.
research Basic research in biostimulation
This study found that low-output laser irradiation demonstrates biostimulatory effects on several biological systems and processes, including hair growth, wound healing, and immune function, with effects influenced by dose and exhibiting both stimulatory and inhibitory potential.