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Combining letrozole with metformin is the most effective treatment for inducing pregnancy in women with PCOS.

Hormone therapy for transgender females increases the risk of blood clots and requires careful dosing, monitoring, and lifelong management.

New signs like changes in blood markers, physical symptoms, and behavioral shifts may help detect hidden steroid use in athletes.

Hormone imbalances can cause specific skin changes, which may help in early detection of endocrine disorders.

Long-term use of finasteride in women can cause hormonal changes, DNA damage, and menstrual issues.

Many women experience sexual dysfunction, but few seek help, and better treatment and medical training are needed.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Women with a certain type of tumor had higher levels of pregnancy hormone and male hormones, which decreased after treatment.

Finasteride effectively treats hair loss and enlarged prostate in men, with mild side effects.

Hair diseases can have psychological effects and should be treated with a combination of psychosomatic care, therapy, and medication.

Mice without the enzyme HSD17B3 still produce normal testosterone, suggesting they have different ways to make it compared to humans.

Environmental factors, hormones, nutrition, and stress all significantly affect skin health and aging.

Insulin resistance may contribute to various skin diseases and treating it could improve skin health and prevent more serious conditions.

Most adrenal cortex tumors are benign and non-secreting, but proper diagnosis and treatment are important due to the rare possibility of cancer.

Nonclassic congenital adrenal hyperplasia is a common genetic disorder that can cause a range of symptoms and requires personalized treatment.

New compounds show promise for treating hair loss, enlarged prostate, and prostate cancer, with some being more effective and having different side effects than current treatments.

Clascoterone is a new, effective, and safe acne treatment without systemic side effects.

Hormones significantly affect women's sexual function, and more research is needed to improve treatments for sexual dysfunction with minimal side effects.

Existing drug dexamethasone may lower death risk in severe COVID-19 cases; more research needed for other drugs.

Men with early balding should be checked for metabolic syndrome, as there's a link between the two.

Pediatric endocrinologists should provide early fertility counseling and preservation options to young patients at risk of infertility.

Both mouse and rat models are effective for testing alopecia areata treatments.

The document concludes that managing non-classical congenital adrenal hyperplasia in females requires personalized treatment, genetic counseling, and a team of specialists.

Acne can't be cured but can be managed with treatments like benzoyl peroxide and diet changes; it's costly and can lead to scarring and mental health issues.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Early-onset baldness is linked to genetics, lifestyle, and can indicate higher risk for heart and metabolic diseases, and affects mental health.

Skin, hair, and nail changes can help detect eating disorders early.

Moderately high prolactin levels do not cause hair loss in women.

Sardinians were historically short due to a mix of genetics and factors like disease and poor nutrition, but recent height increases suggest better living conditions had a bigger impact.

The document concludes that the immune-inhibitory environment of the hair follicle may prevent melanoma development.