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    Glossary Hypopigmentation

    reduced melanin causes lighter skin patches

    Hypopigmentation refers to a condition where patches of skin become lighter than the surrounding area due to a reduction in melanin, the pigment responsible for skin color. This can result from various causes, including skin injuries, certain medical conditions like vitiligo, or inflammatory skin disorders.

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    1. Tyrosinase inhibition due to interaction of homocyst(e)ine with copper: the mechanism for reversible hypopigmentation in homocystinuria due to cystathionine beta-synthase deficiency. PubMed · 1995 · 74 citations
    2. Decrypting the Potential of Nanotechnology-Based Approaches as Cutting-Edge for Management of Hyperpigmentation Disorder Molecules · 2022 · 26 citations
    3. Hypopigmentation in frontal fibrosing alopecia Journal of the American Academy of Dermatology · 2017 · 23 citations
    4. Localised Skin Hyperpigmentation as a Presenting Symptom of Vitamin B12 Deficiency Complicating Chronic Atrophic Gastritis Sultan Qaboos University medical journal · 2015 · 5 citations
    5. Erythromelanosis follicularis faciei et colli with reticulated hyperpigmentation of the extremities Clinical case reports · 2017 · 3 citations
    6. Spontaneous hair hyperpigmentation in response to vitamin intake in pregnancy—A clue for homocystinuria American Journal of Obstetrics and Gynecology · 1995 · 2 citations
    7. Pluripotent Stem Cell Technology: A Promising Remedy for Hypopigmentation Disorders Journal of Stem Cell Research & Therapeutics · 2017 · 1 citations
    8. Hyperpigmentation post laser hair removal in patients taking Vitamin D supplements Journal of Dermatology and Dermatologic Surgery · 2021 · 1 citations
    9. SUCCESSFUL TREATMENT OF LASER-INDUCED HYPOPIGMENTATION WITH PLATELET-RICH PLASMA CASE REPORT International Journal of Advanced Research · 2025
    10. Postsclerotherapy Hyperpigmentation: A Histologic Evaluation The Journal of Dermatologic Surgery and Oncology · 1987 · 119 citations
    11. Reversible Hyperpigmentation of Skin and Nails With White Hair due to Vitamin B12 Deficiency Archives of Dermatology · 1986 · 77 citations
    12. Nail, hair and skin hyperpigmentation associated with indinavir therapy AIDS · 2004 · 15 citations
    13. Reversible hyperpigmentation of skin and nails with white hair due to vitamin B12 deficiency Archives of Dermatology · 1986 · 11 citations
    14. Modified phenol peels for treatment‐refractory hyperpigmentation of lichen planus pigmentosus: A retrospective clinico‐dermoscopic analysis Journal of cosmetic dermatology · 2019 · 8 citations
    15. Genomic and transcriptomic landscape to decipher the genetic basis of hyperpigmentation in Lanping black-boned sheep (Ovis aries) BMC Genomics · 2024 · 7 citations
    16. A case of hyperpigmentation and acanthosis nigricans by testosterone injections Human & experimental toxicology · 2014 · 6 citations
    17. Hyperpigmentation, severe alopecia, and six days of instability in a case of severe methotrexate hypersensitivity reaction Daru · 2021 · 5 citations
    18. Hyperpigmentation following Treatment of Frontal Fibrosing Alopecia Case reports in dermatology · 2013 · 5 citations
    19. Bilaterally Symmetrical Alopecia With Reticulated Hyperpigmentation Veterinary Pathology · 2012 · 5 citations
    20. Fabrication of Thymoquinone and Ascorbic Acid-Loaded Spanlastics Gel for Hyperpigmentation: In Vitro Release, Cytotoxicity, and Skin Permeation Studies Pharmaceutics · 2025 · 4 citations
    21. Sodium Valproate-Induced Hyperpigmentation The Journal of Pediatrics · 2023 · 3 citations
    22. Fat grafts enriched with ex‐vivo expanded adipose stem cells improve hyperpigmentation of face Cell Biology International · 2023 · 3 citations
    23. Contact Dermatitis Associated with Alopecia and Hyperpigmentation Pediatric Dermatology · 2017 · 3 citations
    24. Hyperpigmentation Associated with the Use of Topical Cidofovir for Treatment of Trichodysplasia Spinulosa in an Immunosuppressed Adult: Case Report and Review of the Literature Skin · 2020 · 2 citations
    25. Design and development of cosmeceutical cream for hyperpigmentation and anti-aging International Journal of Advanced Community Medicine · 2018 · 2 citations
    26. Reversible Facial Hyperpigmentation Associated With Vitamin B12 Deficiency Nutrition in clinical practice · 2016 · 2 citations
    27. The Therapeutic and Preventive Effects of Light‐Emitting Diode (LED) for Post‐Inflammatory Erythema and Hyperpigmentation: A Pilot Study Photodermatology Photoimmunology & Photomedicine · 2025 · 1 citations
    28. Skin Hyperpigmentation in Complex Regional Pain Syndrome (CRPS) (P3.315) Neurology · 2015 · 1 citations
    29. Evolution Of Anti-Hyperpigmentation Skincare: From Traditional Remedies To Modern Cosmeceutical Approaches For Adolescents Adolescencia e Saude · 2026
    30. Decoding Hyperpigmentation from Biological Mechanisms to Actives with Clinically Proven Topical Efficacy: A Narrative Review Dermatology and Therapy · 2026