86 citations
,
August 2011 in “Toxicological sciences” In this study, researchers found that TCDD exposure accelerated differentiation and altered gene expression in human epidermal cells, indicating the epidermal barrier as a target of TCDD-activated AHR.
30 citations
,
April 2007 in “Dermatologic Clinics” This review discusses the mechanisms by which isotretinoin and hormonal therapy treat acne through their effects on sebaceous glands, reporting no new clinical results.
16 citations
,
November 2023 in “Scientific Reports” This study developed a niosomal delivery system loaded with tretinoin and bicalutamide, optimized for follicular targeting in acne management, showing promising accumulation in hair follicles in animal models.
13 citations
,
January 2024 in “Cureus” This study reviewed the physiological and psychological impacts of acne vulgaris, highlighting its complex interactions with endocrine issues, sebum production, and immune response, while suggesting that a multidisciplinary approach can inform future treatments and improve quality of life for those affected.
12 citations
,
February 1997 in “British Journal of Dermatology” This study found that 5α–reductase activity is higher in infrainfundibular keratinocytes compared to interfollicular epidermal keratinocytes, suggesting a potential role in acne-related follicular changes.
1 citations
,
January 2023 in “Middle East Research Journal of Pharmaceutical Sciences” This review discusses the mechanisms and grading challenges of acne vulgaris, highlighting the need for better treatment strategies and reports no new experimental results.
March 2026 in “International Journal of Homoeopathic Sciences” This narrative review reports preliminary evidence suggesting that an integrative homeopathic approach, combining constitutional treatment with topical mother tinctures, may aid in healing and reducing inflammatory acne lesions, though larger trials are needed to confirm these effects.
November 2025 in “Cureus” This review discusses the link between PCOS and acne, highlighting the roles of hyperandrogenism and insulin resistance, but it reports no new clinical findings.
January 2018 in “Springer eBooks” The document says that early treatment of Acne Vulgaris is important to prevent scarring and that adult onset acne is common in women, often due to hormonal imbalances.
November 2015 in “International journal of science and research” This study found that adult acne is more inflammatory than adolescent acne and predominantly affects the cheeks, jaw-line, and chin.
April 2024 in “International journal of women's health” This review explores adult female acne, focusing on its multifactorial causes, treatment options, and impact on quality of life, but reports no new clinical results.
134 citations
,
January 2019 in “American journal of clinical dermatology” This review summarizes recent research on the skin microbiome's role in acne development and how antibiotic treatments affect skin microbes, but it reports no new clinical results.
76 citations
,
November 2009 in “Medical Clinics of North America” This article reviews the hormonal and medication-related factors associated with acne development but does not present new research findings.
69 citations
,
November 2010 in “Middle East Fertility Society Journal” This review discusses the multifactorial origins and pathophysiology of PCOS and highlights the effectiveness of lifestyle modifications as a first-line intervention, reporting no new research results.
41 citations
,
April 2010 in “Gender Medicine” This review discusses the causes, clinical features, diagnostic approach, and treatment options for hirsutism in women, but reports no new findings.
38 citations
,
November 2012 in “Expert Opinion on Drug Safety” This article reviews different acne treatments and emphasizes the importance of being aware of their potential side effects, but reports no new clinical results.
33 citations
,
August 2018 in “Facial Plastic Surgery Clinics of North America” This review discusses various biologics for hair aging but reports no agent capable of reversing the natural aging process of hair.
28 citations
,
May 2012 in “Veterinary Dermatology” In this study, dogs with hair cycle disorders, especially those with alopecia X, showed a significant increase in the number of kenogen follicles, suggesting impaired induction of new hair growth phases.
18 citations
,
March 2004 in “Clinics in Dermatology” This review discusses recent advances in understanding the cellular, molecular, and genetic factors contributing to lupus erythematosus and reports no new experimental findings.
18 citations
,
December 1996 in “Seminars in Cutaneous Medicine and Surgery” This article reviews adverse skin reactions caused by chemotherapy and cytokine treatments, describing specific and nonspecific reactions, but reports no new clinical findings.
17 citations
,
January 2013 in “Indian Journal of Pharmacology” This case report highlights an interest in exploring the relationship between serum levels of sodium valproate and hair loss, though no case reports currently establish this link.
17 citations
,
September 2010 in “Pediatric dermatology” This report describes a case of widespread Porokeratotic eccrine and hair follicle nevus in a 15-year-old woman with keratitis-ichthyosis-deafness syndrome, involving both eccrine ostia and hair follicle infundibula.
15 citations
,
December 2016 in “Revista Da Associacao Medica Brasileira” This review examines the literature on polycystic ovary syndrome, focusing on its pathogenesis, diagnosis, and links to cardiovascular and hypertensive disorders, but presents no new clinical findings.
15 citations
,
September 2005 in “The Journal of the American Animal Hospital Association/Journal of the American Animal Hospital Association” This study found that trilostane treatment led to complete hair regrowth in three Alaskan malamutes with ACTH-stimulated elevated 17-hydroxyprogesterone levels within 6 months without any recognized adverse effects.
15 citations
,
July 1999 in “Dermatologic Clinics” This article discusses the potential for targeted therapies in hair loss by exploring inflammatory and cytokine-mediated processes, but it presents no new clinical results.
12 citations
,
October 1995 in “The Journal of Clinical Endocrinology & Metabolism” Skin changes can indicate hormonal imbalances and help diagnose endocrine disorders.
10 citations
,
July 2015 in “Current opinion in pediatrics, with evaluated MEDLINE/Current opinion in pediatrics” This review discusses updates in the genetics and clinical understanding of congenital ichthyosis and highlights the addition of N-acetylcysteine and topical enzyme replacement to the treatment options, without providing new clinical results.
8 citations
,
December 2015 in “Daehan han'yi hag'hoeji/Journal of Korean medicine” This study found that transtherapy, a treatment using Korean medicine, significantly improved acne scars, reducing the scarring grade from an average of 3.5 to 1.5 in moderate and severe cases.
5 citations
,
October 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identified a high-risk allele in the PLCD1 gene associated with hereditary trichilemmal cyst formation, proposing a monoallelic two-hit mechanism as the underlying genetic pathogenesis.
2 citations
,
October 2016 This article discusses the range of skin-related side effects caused by chemotherapy and radiotherapy, including novel patterns emerging with targeted therapies, but does not report new clinical results.