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The review recommends hormone replacement therapy for women with premature ovarian insufficiency to manage symptoms and protect health, with specific approaches for different groups.

Metabolic syndrome and PCOS are related but separate conditions, with metabolic syndrome increasing the risk of heart disease and diabetes.

Fat from the body can help improve hair growth and scars when used in skin treatments.

PPAR agonists show promise for skin conditions but need more research before being a main treatment.

Nanotechnology in dermatology shows promise for better drug delivery and treatment effectiveness but requires more safety research.

Metformin combined with lifestyle changes improves insulin resistance and reduces testosterone levels in women with PCOS more than lifestyle changes alone.

Both drugs lower DHT levels, with GI198745 being more effective.

EdnrB signaling helps melanocyte stem cells regenerate and could be targeted to treat pigmentation issues.

Both mouse and rat models are effective for testing alopecia areata treatments.

Cyclosporin is effective for treating skin conditions in small animals, but requires careful dosing and monitoring for side effects.

Multiphoton microscopy is a promising tool for detailed skin imaging and could improve patient care if its challenges are addressed.

Obese women with PCOS show a male-like pattern in certain fat tissue gene expressions.

Hair loss can indicate underlying systemic diseases and addressing these can sometimes reverse the hair loss.

Different types of androgens bind differently to two receptors, AR1 and AR2, in Atlantic croaker's brain and ovarian tissues, suggesting these receptors may control different androgen actions in fish.

The document concludes that electrolysis and thermolysis can permanently remove hair but calls for better regulation to ensure safety, and notes a possibility of hair regrowth and rare complications.

Celiac disease can cause skin problems that may get better with a gluten-free diet.

5α-reductase inhibitors increase the risk of sexual dysfunction, especially in men with enlarged prostate.

Oral contraceptives help treat hyperandrogenic disorders, improving symptoms like excessive hair and acne.

Minoxidil treats high blood pressure and side effects can be managed.

Androgens play a complex role in skin conditions like acne and hair loss in women, and normal blood levels don't always show true androgen status.

MicroRNAs are crucial for controlling skin development and healing by regulating genes.

Brain hormones significantly affect hair color and could potentially be used to prevent or reverse grey hair.

Different women's hair and skin glands respond to hormones in varied ways, which can cause unwanted hair growth even with normal hormone levels, and more research is needed to treat this effectively.

Early balding linked to higher heart disease risk.

Minoxidil helps hair regrowth in alopecia areata safely.

Ablative fractional resurfacing could improve how well topical drugs penetrate the skin, but more research is needed to fine-tune the method.

Topical latanoprost and bimatoprost eye solutions don't help eyelash growth in people with alopecia areata.

Nonclassic adrenal hyperplasia is a genetic condition that can cause early puberty and fertility problems, treated with specific steroids.

The flexible fixed-sequence testing method allows for more effective evaluation of multiple goals in a clinical trial while controlling the risk of false positives.

Antidepressants called SSRIs can cause skin problems, bleeding risk, and other side effects.