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Self-amplifying RNA could be a better option for protein replacement therapy with lower doses and lasting effects, but delivering it into cells is still challenging.

Nourkrin® with Marilex® may significantly increase hair growth and alopecia could be an early sign of metabolic syndrome.

Hormone therapy increases the risk of heart-related issues in transgender women and may affect heart health in transgender men.

Gender-affirming hormone therapy changes hair growth in transgender people, with feminizing therapy reducing hair and masculinizing therapy increasing it, but sometimes additional treatment is needed.

Long-term testosterone therapy can cause hormone suppression, affect prostate and heart health, and alter physical characteristics, but does not increase prostate cancer risk and needs more research for full risk assessment.

Testosterone replacement therapy can prevent men from fathering children and should not be used by those wanting to stay fertile.

Testosterone replacement therapy helps manage deficiency and has various methods, but requires careful monitoring to avoid side effects.

Androgen Deprivation Therapy for prostate cancer often reduces sexual function but intermittent therapy may be more tolerable.

Hormone therapy increases facial and body hair in transgender men, while hair removal improves well-being in transgender women, but cost is a barrier as insurance often doesn't cover it. Dermatologists can use various treatments for these hair issues.

Testosterone replacement therapy improves libido, mood, muscle strength, and bone density in men with Testosterone Deficiency Syndrome.

The document concludes that non-operative treatment for gender dysphoria is safe and effective, and hormone therapy does not increase cancer risk.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

A young woman with kidney failure had hair loss due to a common hormonal disorder, which improved with hormone therapy.

Testosterone therapy in transgender men has both desired effects like increased muscle mass and potential health risks such as higher cardiovascular risk.

Enzyme replacement therapy may help alleviate symptoms in complex cases like this.

The man's fatigue and erectile dysfunction were improved by treating his obesity-related low testosterone without needing testosterone replacement.

Early medical support for transgender youth is important for their health, with low regret for gender-affirming hormone use and a need for knowledgeable care providers.

Testosterone therapy helps boys with hormone deficiencies develop normal male characteristics and grow properly.

The therapies improved ejaculation disorders and sexual function in middle-aged men.

A 19-year-old male with delayed puberty was successfully treated for a condition that prevents normal hormone production.

Testosterone therapy can modestly improve sexual function in menopausal women but should be used cautiously and is not recommended for routine measurement in sexual dysfunction or hirsutism.

Hormones like estrogen, testosterone, progesterone, and prolactin play complex roles in female sexual function, with testosterone potentially improving sexual desire, arousal, and satisfaction. However, more research is needed to establish safe and effective hormone treatments for female sexual dysfunction.

Testosterone therapy improves physical function, strength, and body composition in older men with low testosterone levels.

Testosterone therapy is generally safe for transmen, improves sexual function, and has manageable health risks with proper monitoring.

Hirsutism is often caused by high male hormone levels and can be treated with lifestyle changes and medications.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

New treatments for male hypogonadism are effective and should be personalized.

Hair loss in women may have causes other than hormones.

Testosterone improves mood and thinking skills; finasteride has no effect.

Late diagnosis of congenital adrenal hyperplasia can greatly affect physical development, gender identity, and sexual health.