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The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

The timing of when the gene Bmal1 is active affects aging and survival, with its absence during development, not adulthood, leading to premature aging.

The Rotterdam Study aims to understand various diseases in older adults.

Mice lacking the PPARγ gene in their fat cells had almost no fat tissue, severe metabolic problems, and abnormal development of other fat-related tissues.

Planarian regeneration begins with a specific gene activation caused by injury, essential for healing and tissue regrowth.

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

Most women with excess hair growth have an underlying hormonal issue, often treated with medication and hair removal methods.

Melatonin may benefit skin health and could be a promising treatment in dermatology.

Alopecia areata involves immune activation in the scalp, suggesting treatments targeting TH1, TH2, and IL-23 pathways.

Chemotherapy can cause skin problems like hair loss, mouth sores, and skin darkening, and recognizing these can affect treatment decisions.

A substance called DKK-1 increases in balding areas and causes hair cells to die when exposed to DHT.

The conclusion is that accurate diagnosis of different types of hair loss requires good teamwork between skin doctors and lab experts.

New insights show Lichen Planopilaris is a rare, scarring hair loss condition, hard to treat, mainly affecting middle-aged women, and significantly impacts mental health.

Chemotherapy-induced hair loss significantly affects patients' well-being, and nurses are key in helping them cope, but more research is needed to find effective treatments.

AXR3 and SHY2 genes control the growth and timing of root hair development in plants.

Alopecia areata causes hair loss, has no cure, and various treatments exist.

Researchers developed promising agents for prostate cancer imaging, with the best one showing high potential for clinical use.

Aging causes skin stem cells to work less effectively.

Hair follicles may soon be used more for targeted and systemic drug delivery.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

Matriptase is crucial for keeping epithelial tissues healthy and functioning properly.

Macrophages help heal nerves by aiding the maturation of Schwann cells and are important for nerve repair.

Eating disorders like anorexia and bulimia cause skin problems, and dermatologists can help detect these disorders early for better treatment outcomes.

Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.

Probiotic bacteria improved skin and hair health in aged mice.

Oxidative stress contributes to hair graying and loss as we age.

Cepharanthine is a well-tolerated drug with multiple medical uses, including anti-inflammatory and anti-cancer properties.

Substances from Chinese medicines show promise for immune support and disease prevention, but the way they are processed affects their effectiveness.

Fat cells in the skin help start healing and form important repair cells after injury.

The document concludes that while significant progress has been made in understanding skin biology and stem cells, more research is needed to fully understand their interactions with their environment.