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The timing of when the gene Bmal1 is active affects aging and survival, with its absence during development, not adulthood, leading to premature aging.

Mice lacking the PPARγ gene in their fat cells had almost no fat tissue, severe metabolic problems, and abnormal development of other fat-related tissues.

Interferon alfa-2a is effective for treating cutaneous T cell lymphoma but has significant side effects.

Overexpressing follistatin in mice delays wound healing and reduces scar size.

Microneedles improve drug delivery in various body parts, are safe and painless, and show promise in cosmetology, vaccination, insulin delivery, and other medical applications.

Traditional Chinese medicines with heavy metals can cause severe poisoning.

Skin problems can be caused or worsened by physical forces and pressure on the skin.

Bariatric surgery can worsen nutritional deficiencies, requiring careful monitoring and supplementation.

Lack of essential fatty acids in diet causes reproductive issues and poor health in male rabbits.

Levetiracetam is widely used and generally well-tolerated for treating idiopathic generalized epilepsies, with tiredness as the main side effect.

Bergamot may improve heart health, skin conditions, and mood, but more research is needed to confirm these benefits.

IGF-1 increases whisker growth in transgenic mice.

Traditional healers in Namibia use 70 different plants to treat AIDS-related diseases, and more research is needed to test these plants' effectiveness against HIV.

Systemic lupus erythematosus is a chronic disease causing inflammation and various symptoms, mainly in young women, treated with anti-inflammatory and immunosuppressive drugs.

Methionine restriction works better than betaine for treating CBS deficiency symptoms in mice.

Both topiramate and divalproex sodium effectively reduce migraine frequency and are generally well-tolerated.

The document concludes that side effects from Smoothened inhibitor drugs for skin cancer are reversible and can be managed with a team approach to maintain quality of life.

Dr. Samuel M. Lam's article concludes that skilled facial fat grafting can effectively restore facial volume and serve as a complement or alternative to traditional face-lifting methods.

Doctors used to view PCOS too narrowly, but now understand that insulin resistance is a key factor in the condition.

Most children with childhood-onset lupus in Baghdad responded well to treatment, but some developed chronic kidney disease or died.

Proper diet management is crucial for phenylketonuria patients to avoid severe health issues.

A man with Cronkhite-Canada syndrome had all 20 nails detach but improved with treatment.

Injecting newborn mice with a niacin blocker caused skin, gut, and brain damage similar to human pellagra.

Weekly azathioprine pulse is a better alternative to corticosteroids for treating alopecia areata due to fewer side effects.

Thorough history taking is crucial for diagnosing hypothyroidism in rheumatoid arthritis patients.

PCOS is a common inherited condition causing cysts, irregular periods, and increased diabetes risk in women.

The document suggests a young mother use effective contraception like the Copper-T IUD while considering her health and the need for STD prevention.

Ginger supplements helped reduce symptoms and improve metabolic health in hypothyroid patients.

The 2023 guideline for PCOS suggests using updated diagnostic criteria, assessing related health risks, and recommends lifestyle changes and specific treatments for symptoms and fertility issues.

Rituximab may be an effective treatment for Cronkhite-Canada syndrome with kidney disease.