February 2026 in “Journal of the Korean Society of Cosmetology” This study found that applying a red clover-chamomile complex extract ampoule for 4 weeks significantly improved hair density and shaft thickness at the hairline in participants with self-perceived decreased density.
July 2026 in “International Journal of Clinical & Experimental Dermatology” This exploratory pilot study reported that using a 2% Oleosome-FGF-2 fusion extract scalp serum twice daily for 84 days in women with telogen effluvium and brittle hair improved hair density, anagen/telogen ratio, hair shaft thickness, and scalp hydration compared to a placebo.
December 2024 in “Skin Appendage Disorders” Traction alopecia reduces hair density and thickness; proper hair care can help prevent it.
3 citations
,
January 2025 in “动物学研究” This study used high-resolution imaging and genetic analysis to investigate hair density in the Dazu black goat, identifying key genes like GJA1 and GPRC5D involved in follicle development and maintenance, and highlighted their role in animal hair density regulation.
61 citations
,
April 2012 in “British Journal of Dermatology” This study analyzed changes in hair diameter and density with age in Caucasian women, highlighting variations in perception of hair amount over time.
25 citations
,
August 2015 in “Journal of cosmetic dermatology” This study observed significant differences in hair care practices and biologic hair parameters between Caucasian and African American women, which may contribute to varying hair fragility and growth.
16 citations
,
January 2002 in “Dermatology” This study found that the parietal/occipital hair density ratio decreases significantly only when baldness is visibly present, making it no better than the Hamilton/Norwood scale for assessing baldness severity.
6 citations
,
January 2016 in “Annals of Dermatology” This study found that glycosaminoglycan levels were higher in the occipital area of the hair shaft compared to the parietal area, with children showing higher levels than adults.
September 2022 in “International Journal of Trichology” This study found that trichoscopic measurements of hair density and diameter are useful for assessing the severity of female pattern hair loss and its progression.
January 2025 in “International Journal of Dermatology” This study observed that indigenous South Africans with natural afro-textured hair have lower hair densities, varying shaft diameters, and distinct follicular unit patterns compared to other racial groups, with significant gender differences in some parameters, highlighting the need for tailored reference values in clinical settings.
68 citations
,
March 2018 in “Biomaterials” This study found that in vivo, a novel microneedle system for valproic acid delivery may improve hair regrowth efficacy by upregulating hair follicle development pathways more effectively than topical application.
92 citations
,
September 2019 in “ACS nano” This study observed that a wearable electric stimulation device significantly promoted hair regeneration in rats and mice, outperforming conventional pharmacological treatments and enhancing growth factor secretion.
57 citations
,
November 1987 in “Pediatric Dermatology” This article reviews common hair growth abnormalities in children, emphasizing the importance of distinguishing normal development from potential signs of metabolic disorders and indicates no new clinical results.
42 citations
,
June 2019 in “Aging” This study found that treatment with the polyphenolic compound TCQA activated β-catenin, promoting hair regrowth and the initiation of the anagen phase in mice and human dermal papilla cells.
16 citations
,
November 2011 in “PubMed” This study found that a single intradermal injection of Hair Stimulating Complex significantly improved hair growth in men with androgenetic alopecia compared to placebo.
3 citations
,
January 2021 in “Hair transplant forum international” This study found that visual hair density is better correlated with hair count and shaft diameter, leading to the development of the Hair Diameter Index used in planning hair restoration procedures.
July 2026 in “Aesthetic Plastic Surgery” This pilot study found that intradermal 10% glucose combined with non-cross-linked hyaluronic acid improved hair density and diameter more than hyaluronic acid alone in adults with androgenetic alopecia, with no serious adverse events.
25 citations
,
November 2012 in “Phytotherapy Research” In this study, oral administration of Crataegus pinnatifida extract was associated with hair growth promotion in mice by inducing anagen phase and enhancing cell signaling related to hair follicle development.
23 citations
,
June 2021 in “Lasers in Medical Science” In this study, blue light therapy at a specific wavelength increased hair density and shaft width in 90% of patients with androgenetic alopecia after 10 weeks.
1 citations
,
March 2021 in “Frontiers in Medicine” In this study, female pattern hair loss in Chinese Han patients was characterized by decreased hair density and shaft diameter, with minor gender differences and the vertex most affected.
September 2024 in “Pakistan Journal of Science” This systematic review suggests that laser treatments, especially low-level laser therapy and excimer lasers, may be effective for hair regrowth, though further large-scale studies are needed for validation.
December 2023 in “Siriraj Medical Journal” This study found that 5% azelaic acid solution and 2% minoxidil solution both significantly increased hair density and shaft diameter in women with FPHL, with no significant differences between them.
26 citations
,
May 2017 in “Lasers in Medical Science” This study found that combining ablative fractional CO₂ laser therapy with hair growth factors significantly increased hair density in men with androgenetic alopecia compared to using growth factors alone.
17 citations
,
November 2012 in “Maturitas” This review discusses the management of hair loss in midlife women, focusing on female pattern hair loss, hair shaft alterations from hair care, and telogen effluvium, and reports no new research findings.
11 citations
,
January 2017 in “Evidence-based Complementary and Alternative Medicine” This study investigated the effects of the herbal formulation DA-5512 on hair growth, finding that it significantly promotes dermal papilla cell proliferation and stimulates hair growth in mice while showing efficacy and safety in human trials compared to placebo and minoxidil (3%).
9 citations
,
January 2018 in “Dermatologic Therapy” In this study, the HairLux fractional radiofrequency device was found to be effective and safe for stimulating hair growth in androgenetic alopecia, with patients experiencing increased hair density and thickness after ten treatments.
2 citations
,
July 2022 in “Frontiers in Medicine” This study found that combining topical minoxidil with microneedling improved hair density more than either minoxidil alone or with spironolactone for women with mild-to-moderate female pattern hair loss.
2 citations
,
May 2022 in “Clinical, Cosmetic and Investigational Dermatology” This study reports that quantitative trichoscopy, while noninvasive and convenient, provides less accurate hair density data compared to invasive histopathologic examination, which was demonstrated in a sample of adult Chinese individuals without alopecia.
1 citations
,
April 2023 in “Biomolecules” This study found that hair care products containing fermented papaya, fermented mangosteen, and caffeine significantly inhibited hair loss, increased hair density and thickness, and improved hair follicle structure in individuals with androgenic or diffuse alopecia over three months compared to placebo and caffeine controls.
July 2026 in “Journal of Cutaneous and Aesthetic Surgery” This study found that trichoscopic quantitative parameters reliably indicate the severity of female pattern hair loss and complement the Sinclair scale by offering a more objective and reproducible grading system.