67 citations
,
April 1988 in “The Journal of Clinical Endocrinology & Metabolism” This study describes a family with X-linked gynecomastia and undervirilization in men, finding a subtle androgen receptor abnormality that may not always lead to infertility despite androgen resistance.
49 citations
,
December 1997 in “Urology” This study found that low-dose tamoxifen may effectively treat painful gynecomastia in patients receiving flutamide and finasteride for advanced prostate cancer.
36 citations
,
January 1991 in “PubMed” In this pilot study, 2% topical Minoxidil showed no benefit in preventing hair loss during chemotherapy for gynecologic cancers, although it was non-toxic.
30 citations
,
April 2002 in “Archives of Dermatology” Finasteride can cause one-sided breast enlargement, which disappears after stopping the drug.
29 citations
,
January 2009 in “International Journal of Trichology” This report describes two cases of gynecomastia linked to the use of Finasteride (Propecia®) for treating androgenetic alopecia, highlighting a rare but important side effect.
15 citations
,
June 1995 in “The American Journal of the Medical Sciences” This study describes a case where finasteride treatment for benign prostatic hypertrophy was associated with gynecomastia in a 62-year-old man, which resolved after the drug was discontinued.
14 citations
,
September 2017 in “Clinics in Dermatology” This study highlights that lower testosterone in men and higher testosterone in women are linked to increased risks of metabolic syndrome and type 2 diabetes, with associated skin diseases indicating potential cardiovascular complications.
14 citations
,
August 1997 in “The Journal of Urology” Finasteride can cause enlarged breasts.
10 citations
,
September 2007 in “Pediatrics in Review” This review discusses the hormonal and pathological factors contributing to gynecomastia and premature thelarche in children but presents no new clinical findings; the authors emphasize the need for careful evaluation.
8 citations
,
January 2009 in “Indian Journal of Dermatology, Venereology and Leprology” Finasteride can cause rare breast growth side effect, with varying recovery after stopping.
3 citations
,
September 2019 in “American Journal of Men's Health” This study suggests that continuing finasteride therapy after mastectomy does not significantly affect gynecomastia recurrence in men taking finasteride for alopecia.
3 citations
,
November 2022 in “Frontiers in oncology” This study found that while serum zinc concentrations were not associated with developing gynecologic cancers, zinc deficiency was linked to a higher recurrence rate.
3 citations
,
June 2004 in “Annales De Dermatologie Et De Venereologie” This review summarizes the adverse effects associated with 5α‐reductase inhibitors, noting slightly increased rates of decreased libido, erectile and ejaculatory dysfunction, gynecomastia, depression, and anxiety, with further studies needed to explore symptom prevalence and persistence.
3 citations
,
October 1995 in “Southern Medical Journal” Finasteride may cause breast enlargement, low testosterone a risk factor.
2 citations
,
July 2017 in “Oman medical journal” This report describes a rare case of a malignant feminizing adrenocortical tumor in a 44-year-old man who lacked the typical presentation of gynecomastia and died four months after diagnosis despite treatment.
2 citations
,
January 2003 in “Journal of Clinical Dermatology” This report documents the first cases in Korea of painful bilateral gynecomastia associated with taking 1mg of oral finasteride (Propecia) for male androgenetic alopecia.
September 2023 in “Reproductive health of woman” This review examines the prevalence and symptoms of polycystic ovary syndrome (PCOS) across different ages, highlighting its varied dermatological and reproductive implications, but reports no new research findings.
January 2026 in “Archive ouverte UNIGE (University of Geneva)” This narrative review examined skin-sparing techniques in gynecomastia surgery and found satisfactory thoracic remodeling with acceptable morbidity and reduced scarring, but acknowledged methodological differences that limit decisive conclusions.
September 2025 in “Journal of Psychiatry Spectrum” This case report describes a rare instance of gynecomastia in a male patient undergoing mirtazapine treatment for depression, suggesting the drug as a probable cause after ruling out other factors.
April 2024 in “JCEM case reports” This case report highlights a persistent gynecomastia in a young man following low-dose finasteride, suggesting that the incidence may be underreported and calls for patient counseling and early intervention.
March 2020 in “European Journal of Pediatric Dermatology” This article highlights that isotretinoin can rarely cause persistent sexual dysfunction, similar to finasteride and certain antidepressants, a side effect not mentioned in the drug’s data sheet.
March 2016 in “Korean Journal of Medicine” This study reported that doxazosin may result in gynecomastia after administration but evidence and expert reviews on this are still lacking domestically.
October 2015 in “药物不良反应杂志” This review describes drug-induced gynecomastia, which results from an imbalance between estrogen and androgen action, listing potential treatments but no new clinical results.
7 citations
,
June 2006 in “Pediatrics in Review” This review covers gynecologic examination challenges and normal anatomical variations in prepubertal girls, emphasizing the importance of distinguishing common benign conditions from rare abuse cases; it presents no new experimental findings.
September 2025 in “International Journal of Innovative Technologies in Social Science” This study reviewed aesthetic gynecology procedures, reporting that most are safe, well tolerated, and yield high patient satisfaction, particularly for postmenopausal and postpartum women. However, the study highlights the need for standardized protocols and long-term data.
April 2019 in “Journal of Investigative Dermatology” This study suggests that hormone replacement therapy and oral contraception may have a protective role in scarring alopecia, as these were reported less frequently by patients with the condition compared to those with female pattern hair loss.
January 2019 in “Obstetrics & Gynecology International Journal” This study found that acne prevalence varies among ethnic groups and is often linked to gynecological disorders in women, with hormonal changes as a common factor.
November 2004 in “Postgraduate obstetrics & gynecology” This article reviews the diagnostic criteria for metabolic syndrome, its impact on obstetrics and gynecology practices, and the distinctions between impaired glucose tolerance and impaired fasting glucose, but presents no new clinical findings.
86 citations
,
May 2013 in “American journal of obstetrics and gynecology” This article reviews the care of transgender patients, encompassing diagnosis, treatment options, and challenges in health care access, but does not present new research findings; the authors emphasize the critical role of providers in addressing transgender health needs.
4 citations
,
December 2021 in “Archivio italiano di urologia andrologia” This review found that patients taking antiandrogens, 5 alpha-reductase inhibitors, and spironolactone have an increased risk of developing gynecomastia, potentially due to hormonal changes.